Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon “grosso”

Ballabeni, Vigilio; Tognolini, Massimiliano; Chiavarini, M.; Impicciatore, M; Bruni, Renato; Bianchi, Alberto; Barocelli, Elisabetta

doi:10.1016/j.phymed.2004.01.002

Cited by 56 publications

(33 citation statements)

References 19 publications

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“…The essential oil of lavender, (Lavandula hybrida Reverchon cv. ), showed a broad spectrum antiplatelet effect and was able to inhibit platelet aggregation induced by ADP, arachidonic acid, collagen and the stable thromboxane receptor agonist U46619 with no prohemorrhagic properties (Ballabenia et al, 2004). Linalyl acetate (36% of lavender oil) seemed to be the main active antiplatelet agent.…”

Section: Essential Oils and Cardiovascular Diseases Atherosclerosismentioning

confidence: 99%

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Edris

2007

Phytotherapy Research

1,095

688

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Essential oils and their volatile constituents are used widely to prevent and treat human disease. The possible role and mode of action of these natural products is discussed with regard to the prevention and treatment of cancer, cardiovascular diseases including atherosclerosis and thrombosis, as well as their bioactivity as antibacterial, antiviral, antioxidants and antidiabetic agents. Their application as natural skin penetration enhancers for transdermal drug delivery and the therapeutic properties of essential oils in aroma and massage therapy will also be outlined.

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Section: Essential Oils and Cardiovascular Diseases Atherosclerosismentioning

confidence: 99%

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Edris

2007

Phytotherapy Research

1,095

688

View full text Add to dashboard Cite

show abstract

“…Grosso demonstrated a broad-spectrum antiplatelet effect (i.e., mimicking a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation, and are effective in the arterial circulation where anticoagulants have little effect), and was able to inhibit platelet aggregation induced by ADP, arachidonic acid, collagen and the stable thromboxane receptor agonist U46619 with no prohemorrhagic properties (13). Linalyl acetate, the acetate ester of linalool (36% of lavender oil and a naturally occurring phytochemical found in many flowers and spice plants), appeared to be the main active antiplatelet agent.…”

Section: Introductionmentioning

confidence: 99%

Physical Properties of Gum Karaya-Starch-Essential Oil Patches

2010

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Abstract. Essential oils are used in foods, cosmetics, and pharmaceuticals. Despite the recent marketing of novel essential-oil-containing patches, there is no information on their production, constituents, or physical properties. The objectives of this study were to produce essential-oil patches and characterize their physical properties. The essential oil of Lavandula angustifolia (lavender) was included at concentrations of 2.5% to 10% in patches manufactured from the exudate gum karaya, propylene glycol, glycerol, emulsifier, and optionally, potato starch as filler. Inclusion of essential oil reduced patch strength, stiffness, and elasticity relative to patches without essential oil. Inclusion of starch in the essential-oil patches strengthened them, but reduced their elasticity. Patches' adhesion to substrate was examined by both peeling and probe-tack tests: the higher the inclusion of essential oils within the patch, the larger the decrease in its adhesion to substrate. Addition of starch to essential-oil-containing patches increased their adhesion relative to their essential-oil-only counterparts. Scanning electron micrographs of the patches provided evidence of entrapped starch granules. Although inclusion of essential oil reduced both the mechanical properties and adhesion of the patches, a high proportion of essential oil can still be included without losing patch integrity or eliminating its adhesiveness to the skin.

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“…Furthermore, it is suggested that the antiplatelet activity of the Goniothalamus oils may not be due solely to any individual component but could be due to the synergistic effect of a combination of its compounds. This theory is supported by another experimental model (in mice) that shows for the first time that Lavandula hybrida oil (also known as lavender oil) has antiplatelet/antithrombotic properties which could also be due to a synergistic effect of its components [43]. Further studies are required to investigate the overall antiplatelet, synergistic effects caused by the combination of components making up the essential oils of the Goniothalamus species.…”

Section: +mentioning

confidence: 85%

Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists

Jagroop

2013

Purinergic Signalling

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Adenosine diphosphate (ADP) plays a pivotal role in platelet activation. Platelet hyperactivity is associated with vascular disease and also has a key role in haemostasis and thrombosis. ADP activates platelets through three purinoceptor subtypes, the G q -coupled P2Y 1 receptor, G icoupled P2Y 12 receptor and P2X 1 ligand-gated cation channel. Platelet ADP purinergic receptors are therefore suitable targets for antiplatelet drugs. Thienopyridines such as clopidogrel and ticlopidine, as well as other ADP receptor antagonists like prasugrel, ticagrelor, cangrelor and elinogrel have demonstrated clinical benefits via the inhibition of the selective purinergic ADP receptor, P2Y 12 . However, they still have limitations in their mode of action and efficacy, like increased risk of bleeding. Thus, the ongoing pursuit to develop newer and more effective antiplatelet agents continues. There is a growing interest in the purinergic antiplatelet properties exhibited by plant extracts. This article considers the following: pomolic acid isolated from Licania pittieri, brazilin isolated from the heartwood of Caesalpinia sappan L, phylligenin isolated from the twigs of Muraltia vulpina , bark oil of Gonystylus velutinus , seed and bark extracts from Aesculus hippocastanum L . and red wine phenolics and catechins isolated from green tea. Moreover, the method used to investigate platelet purinergic receptors should be considered, since using a more sensitive, highresolution platelet sizer can sometimes detect platelet variations when the light transmission method was not able to do so. The exact mechanisms by which these plant extracts work need further investigation. They all however inhibit ADP-induced activation in human platelets. This could explain, at least in part, the protective effect of plant extracts as antiplatelet agents.

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Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon “grosso”

Cited by 56 publications

References 19 publications

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Physical Properties of Gum Karaya-Starch-Essential Oil Patches

Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists

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