Novel Antipsychotic Drugs Approved in 2015: Brexpiprazole, Cariprazine, Aripiprazole Lauroxil

Abstract

Antipsychotic agents, highly benefit for the treatment of a range of psychiatric disorders and act by blocking dopamine receptors in the brain and interfering with dopaminergic transmission. Schizophrenia and mania which are psychosis are treated by antipsychotic drugs. These medicines are classified as typical or atypical antipsychotic drugs. The recently developed drugs which are named 'atypical antipsychotics' are useful in patients that do not respond to treatment with other typical antipsychotics. This review puts emphasis on the recent progress in therapeutically attractive piperazine derivatives being novel atypical antipsychotics that were apporved in 2015. Differences in safety-tolerability, affected receptors, activity, side effects are displayed in this review.