Novel applications of nonwood cellulose for blood typing assays

Casals‐Terré, Jasmina; Farré-Lladós, Josep; Zuñiga, Allinson.; Roncero, M. Blanca; Vidal, Teresa

doi:10.1002/jbm.b.34245

Cited by 8 publications

(9 citation statements)

References 25 publications

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“…Casals-Terré et al studied the application of nonwood cellulose (sisal fibers) for blood typing assays. Unrefined sisal paper of 50 and 100 g/m 2 basis weight and pore size >15 μm showed a higher grayscale intensity than that of refined paper, and maximum capillary rise as compared to the Whatman substrates …”

Section: Key Characteristics Of the Paper-based Devicesmentioning

confidence: 88%

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Microfluidics-Based Blood Typing Devices: An In-Depth Overview

Jayachandran,

Parween,

Asthana

et al. 2023

ACS Appl. Bio Mater.

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Identification of correct blood types holds paramount importance in understanding the pathophysiological parameters of patients, therapeutic interventions, and blood transfusion. Considering the wide applications of blood typing, the requirement of centralized laboratory facilities is not well suited on many occasions. In this context, there has been a significant development of such blood typing devices on different microfluidic platforms. The advantages of these microfluidic devices offer easy, rapid test protocols, which could potentially be adapted in resource-limited settings and thereby can truly lead to the decentralization of testing facilities. The advantages of pump-free liquid transport (i.e., low power consumption) and biodegradability of paper substrates (e.g., reduction in medical wastes) make it a more preferred platform in comparison to other microfluidic devices. However, these devices are often coupled with some inherent challenges, which limit their potential to be used on a mass commercial scale. In this context, our Review offers a succinct summary of the recent development, especially to understand the importance of underlying facets for long-term sustainability. Our Review also delineates the role of integration with digital technologies to minimize errors in interpreting the readouts.

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Section: Key Characteristics Of the Paper-based Devicesmentioning

confidence: 88%

“…Unrefined sisal paper of 50 and 100 g/m 2 basis weight and pore size >15 μm showed a higher grayscale intensity than that of refined paper, and maximum capillary rise as compared to the Whatman substrates. 30 6.3.3. Nitrocellulose.…”

Section: Key Characteristics Of the Paper-based Devicesmentioning

confidence: 99%

Microfluidics-Based Blood Typing Devices: An In-Depth Overview

Jayachandran,

Parween,

Asthana

et al. 2023

ACS Appl. Bio Mater.

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“…Whatman grade 5 paper, bought from @Fisher Scientific, is used as the assay substrate. Porous media are tortuous matrices of fibers that are packed together creating some voids (or in other words; pores) [35]. The fluid flows within the pores and is affected by the size of the pores and their distribution.…”

Section: Porous Mediummentioning

confidence: 99%

Flow Control in Porous Media: From Numerical Analysis to Quantitative μPAD for Ionic Strength Measurements

Mehrdel

Khosravi

Karimi

et al. 2021

Sensors

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Microfluidic paper-based analytical devices (µPADs) are a promising technology to enable accurate and quantitative in situ assays. Paper’s inherent hydrophilicity drives the fluids without the need for external pressure sources. However, controlling the flow in the porous medium has remained a challenge. This study addresses this problem from the nature of the paper substrate and its design. A computational fluid dynamic model has been developed, which couples the characteristics of the porous media (fiber length, fiber diameter and porosity) to the fluidic performance of the diffusion-based µPAD sensor. The numerical results showed that for a given porous membrane, the diffusion, and therefore the sensor performance is affected not only by the substrate nature but also by the inlets’ orientation. Given a porous substrate, the optimum performance is achieved by the lowest inlets’ angle. A diffusion-based self-referencing colorimetric sensor was built and validated according to the design. The device is able to quantify the hydronium concentration in wines by comparison to 0.1–1.0 M tartaric acid solutions with a 41.3 mM limit of detection. This research showed that by proper adjustments even the simplest µPADs can be used in quantitative assays for agri-food applications.

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“…These properties make cellulose an attractive material for engineering advanced applications such as low-cost, biodegradable, and disposable biodiagnostics (Su et al, 2012; Arcot et al, 2015), point of care analytical devices (Cranston et al, 2010), and membranes (Sukma and Culfaz-Emecen, 2018) for separation (dialysis). Currently, the main biomedical applications of cellulose include biodiagnostics, such as blood typing (Guan et al, 2014; Li et al, 2014; Casals-Terre et al, 2018), and pregnancy tests (Halpern et al, 2008; Koczula and Gallotta, 2016), tissue engineering (Courtenay et al, 2018; Torgbo and Sukyai, 2018; Curvello et al, 2019), scaffolds (Novotna et al, 2013; Modulevsky et al, 2014; Demitri et al, 2016; Courtenay et al, 2017; O'donnell et al, 2018), eye care solutions (Vehige et al, 2003; Luchs, 2010; Nguyen and Latkany, 2011; Racic et al, 2019), coatings (Jimenez et al, 2017; Spera et al, 2017; Sharif Hossain et al, 2018), packaging (Czaja et al, 2007; Sunasee et al, 2016; Shaghaleh et al, 2018), and sensors (Zhu et al, 2014; Ummartyotin and Manuspiya, 2015; Chen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nano-Films as Bio-Interfaces

Raghuwanshi

Garnier

2019

Front. Chem.

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Cellulose, the most abundant polymer on earth, has enormous potential in developing bio-friendly, and sustainable technological products. In particular, cellulose films of nanoscale thickness (1–100 nm) are transparent, smooth (roughness <1 nm), and provide a large surface area interface for biomolecules immobilization and interactions. These attractive film properties create many possibilities for both fundamental studies and applications, especially in the biomedical field. The three liable—OH groups on the monomeric unit of the cellulose chain provide schemes to chemically modify the cellulose interface and engineer its properties. Here, the cellulose thin film serves as a substrate for biomolecules interactions and acts as a support for bio-diagnostics. This review focuses on the challenges and opportunities provided by engineering cellulose thin films for controlling biomolecules interactions. The first part reviews the methods for preparing cellulose thin films. These are by dispersing or dissolving pure cellulose or cellulose derivatives in a solvent to coat a substrate using the spin coating, Langmuir-Blodgett, or Langmuir-Schaefer method. It is shown how different cellulose sources, preparation, and coating methods and substrate surface pre-treatment affect the film thickness, roughness, morphology, crystallinity, swelling in water, and homogeneity. The second part analyses the bio-macromolecules interactions with the cellulose thin film interfaces. Biomolecules, such as antibodies and enzymes, are adsorbed at the cellulose-liquid interface, and analyzed dry and wet. This highlights the effect of film surface morphology, thickness, crystallinity, water intake capacity, and surface pre-treatment on biomolecule adsorption, conformation, coverage, longevity, and activity. Advance characterization of cellulose thin film interface morphology and adsorbed biomolecules interactions are next reviewed. X-ray and neutron scattering/reflectivity combined with atomic force microscopy (AFM), quartz crystal microbalance (QCM), microscopy, and ellipsometer allow visualizing, and quantifying the structural morphology of cellulose-biomolecule interphase and the respective biomolecules conformations, kinetics, and sorption mechanisms. This review provides a novel insight on the advantages and challenges of engineering cellulose thin films for biomedical applications. This is to foster the exploration at the molecular level of the interaction mechanisms between a cellulose interface and adsorbed biomolecules with respect to adsorbed molecules morphology, surface coverage, and quantity. This knowledge is to engineer a novel generation of efficient and functional biomedical devices.

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Novel applications of nonwood cellulose for blood typing assays

Cited by 8 publications

References 25 publications

Microfluidics-Based Blood Typing Devices: An In-Depth Overview

Microfluidics-Based Blood Typing Devices: An In-Depth Overview

Flow Control in Porous Media: From Numerical Analysis to Quantitative μPAD for Ionic Strength Measurements

Cellulose Nano-Films as Bio-Interfaces

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