In recent years, substantial investments in structural construction underscore the paramount importance of ensuring structural integrity for safety and dependability. Structural Health Monitoring (SHM) has emerged as a pivotal tool for assessing structural health, with an emphasis on damage detection, localisation, and quantification, particularly through vibration-based methods that exploit variations in modal properties as precursors to structural damage. This study presents an innovative methodology that synergistically combines Proper Orthogonal Decomposition and Radial Basis Function interpolation for predicting structural responses based on crack parameters. Additionally, the YUKI algorithm, leveraging population clustering for optimisation, is introduced. The approach is rigorously assessed through experimental analysis of two distinct beams (Beam I and Beam II) exhibiting varying crack depths. The results demonstrate the effectiveness of the POD-RBF-YUKI approach, indicating a notable level of accuracy and consistency. Comparative