Novel Approach for Delivery of Insulin Loaded Poly(lactide-co-glycolide) Nanoparticles Using a Combination of Stabilizers

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

“…In addition, this salt decreases protein solubility with minimal denaturant effect which allows to optimize the amount of protein precipitates (Giteau et al, 2008a;Karam et al, 2014;Penna et al, 2013). Poloxamer 188 was used in order to enhance protein stability and reduce polymer-protein interactions during the encapsulation as described in many studies (Blanco and Alonso, 1998;Kumar et al, 2007;Paillard-Giteau et al, 2010). GF and DMI are injectable water-miscible organic solvents which play here a role of anti-solvent of the protein .…”

Modified drug release of poloxamer matrix by including water-soluble and water-insoluble polymer

“…Drug release is dependent on the dissolution of the gel, which is a zero-order release process 12 . Because of these characteristics, poloxamer 407 has been used as a potential candidate in several controlled release systems [13][14][15] . Recently, a procedure was developed to reduce the particle size of poloxamer to 50 μm.…”

Controlled Delivery of Basal Level of insulin From Chitosan–Zinc–Insulin-Complex-Loaded Thermosensitive Copolymer

“…Some of the approaches that have been tried in order to reduce the initial burst of insulin and to control the release duration and stabilization of insulin are PEGylation of insulin and addition of zinc salts, ethanol and/or glycerol, hydroxypropyl-$-cyclodextrins, sugars, salts, cationic polyelectrolyte, and nonionic and ionic surfactants to insulin. 2,[7][8][9][10][11][12][13][14] A combination approach of two or more delivery systems such as nanoparticle-microsphere or microsphere-hydrogel has also been tried to control and prolong the release behavior of various proteins. [15][16][17][18] However, development of microparticleor nanoparticle-based delivery systems involve complicated manufacturing procedure, low drug loading, and low protein stability due to the presence of organic solvents, heat, and agitation.…”