This paper evaluated the feasibility of using the horizontal radial plume mapping (HRPM) technique to locate multiple emission sources via computational simulation. Seventy-two test maps, each having two Gaussian distributions, were generated in a twodimensional domain. The HRPM technique with the non-negative least square (NNLS) algorithm was then applied to reconstruct the plumes, assuming a nine-beam scanning beam geometry. The NNLS algorithm successfully reconstructed the source locations of 68 of the 72 test maps. However, when one of the plumes was near the origin, the NNLS did not always identify the peak locations correctly. Furthermore, when the two plumes were spaced closely, the NNLS tended to reconstruct a wide plume covering both plumes instead of separating them due to the resolution limitation of the current nine-beam geometry. In the sensitivity analysis, five sets of random error (1%, 5%, 10%, 20%, and 30%) were added in the path-integrated concentration (PIC) from the 72 test maps, and thus, an additional 360 reconstructions were implemented. Robust results were obtained when the noise added was less than 20%. The results generally support the implementation of the NNLS algorithm in the HRPM technique as described in the U.S. Environmental Agency (EPA) Other Test Method 10 (OTM-10).Implications: The methodology evaluated in this paper provides near-real-time estimates about the locations of multiple emission sources. The involved optical remote sensing instruments can monitor large spatial areas (e.g., landfills) in a costeffective way.