Novel approach in the treatment of a persistent iatrogenic parotid fistula using AlloDerm® – an allogenic acellular dermal matrix

Blythe, J.; Koraitim, Mohamed; Arcuri, Francesco; Brennan, Peter A.

doi:10.1016/j.bjoms.2015.09.013

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Parotid fistulas can be treated with other treatment modalities such as botulinum toxin A, hyoscine, cyanoacrylate glue, and alloderm to name a few. [8910] However, keeping in mind the availability of the drug and socioeconomic condition of the patient, total parotidectomy was carried out.…”

Section: Discussionmentioning

confidence: 99%

Management of maxillofacial injuries sustained after a bear attack

Nath¹,

Imran

Megu³

et al. 2018

Ann Maxillofac Surg

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There is a little available literature on injuries sustained due to bear attacks and their management. Bears are agile wild animals and injuries sustained after a bear attack have varying patterns. In general, such cases present to the emergency department with severe maxillofacial injuries with varying patterns, thereby limiting the use of common protocol for the management of such injuries. The aim of this article is to add to the current available literature on bear attacks, a present case of management of maxillofacial injury involving the orbit sustained after a bear attack.

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Section: Discussionmentioning

confidence: 99%

Management of maxillofacial injuries sustained after a bear attack

Nath¹,

Imran

Megu³

et al. 2018

Ann Maxillofac Surg

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“…132 Of note, one study reported complete root coverage in only 42.86% of patients using PADM. 133 There is a growing body of research evaluating ADMs in other conditions, including gingival fenestrations, 134 persistent parotid fistulas, 135 ora-antral fistulas, 136 alveolar bone loss/grafting 137,138 and dental implants. [139][140][141] Generally, ADMs were used to limit donor tissue harvest, 134 promote soft tissue growth 137,139 and improve aesthetic outcomes.…”

Section: Orthopaedic Surgerymentioning

confidence: 99%

Clinical applications of acellular dermal matrices: A review

Petrie

Cox

Becker

2022

Scars, Burns & Healing

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Introduction The extracellular matrix (ECM) plays an integral role in wound healing. It provides both structure and growth factors that allow for the organised cell proliferation. Large or complex tissue defects may compromise host ECM, creating an environment that is unfavourable for the recovery of anatomical function and appearance. Acellular dermal matrices (ADMs) have been developed from a variety of sources, including human (HADM), porcine (PADM) and bovine (BADM), with multiple different processing protocols. The objective of this report is to provide an overview of current literature assessing the clinical utility of ADMs across a broad spectrum of applications. Methods PubMed, MEDLINE, EMBASE, Scopus, Cochrane and Web of Science were searched using keywords ‘acellular dermal matrix’, ‘acellular dermal matrices’ and brand names for commercially available ADMs. Our search was limited to English language articles published from 1999 to 2020 and focused on clinical data. Results A total of 2443 records underwent screening. After removing non-clinical studies and correspondence, 222 were assessed for eligibility. Of these, 170 were included in our synthesis of the literature. While the earliest ADMs were used in severe burn injuries, usage has expanded to a number of surgical subspecialties and procedures, including orthopaedic surgery (e.g. tendon and ligament reconstructions), otolaryngology, oral surgery (e.g. treating gingival recession), abdominal wall surgery (e.g. hernia repair), plastic surgery (e.g. breast reconstruction and penile augmentation), and chronic wounds (e.g. diabetic ulcers). Conclusion Our understanding of ADM’s clinical utility continues to evolve. More research is needed to determine which ADM has the best outcomes for each clinical scenario. Lay Summary Large or complex wounds present unique reconstructive and healing challenges. In normal healing, the extracellular matrix (ECM) provides both structural and growth factors that allow tissue to regenerate in an organised fashion to close the wound. In difficult or large soft-tissue defects, however, the ECM is often compromised. Acellular dermal matrix (ADM) products have been developed to mimic the benefits of host ECM, allowing for improved outcomes in a variety of clinical scenarios. This review summarises the current clinical evidence regarding commercially available ADMs in a wide variety of clinical contexts.

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“…The use of hADMs of different thicknesses after parotidectomy has been shown to decrease the incidence of Frey syndrome and to excellently repair a persistent iatrogenic parotid fistula. 33,34 The suggested method is to implant a 1-mm thick sheet of hADM to act as a barrier between the parotid bed and the dermal flap. Some authors also suggested that providing the hADM between the severed postganglionic autonomic fibers of the parotid gland and the overlying sweat glands, can prevent aberrant innervation.…”

Section: Parotid Areamentioning

confidence: 99%

Section: Head and Neckmentioning

confidence: 99%

The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (eg, tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices.

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Novel approach in the treatment of a persistent iatrogenic parotid fistula using AlloDerm® – an allogenic acellular dermal matrix

Cited by 4 publications

References 5 publications

Management of maxillofacial injuries sustained after a bear attack

Management of maxillofacial injuries sustained after a bear attack

Clinical applications of acellular dermal matrices: A review

The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

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