Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertension

Hirose, Katsumi; Marui, Akira; Arai, Yoshinori; Kubota, Toshihiro; Kimura, Yu; Sakaguchi, Hisashi; Yuang, Huang; Chandra, Bhopal; Ikeda, Tadashi; Amano, Shigeru; Tabata, Yasuhiko; Komeda, Masashi

doi:10.1016/j.jtcvs.2008.05.038

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…The same group has developed gelatin particles for the treatment of arteriosclerosis obliterans by the release of erythropoietin,12 regeneration of intravertebral disc by the delivery of platelet‐rich plama,77 and osteoarthritis using basic fibroblastic growth factor (bFGF) testing their effectiveness in animal models 78. More works using microparticles in this ambit have been developed by these authors regarding osteochondral regeneration as well as the induction of angiogenesis 79–82…”

Section: Applications Of Microparticles In Tissue Engineering and Regmentioning

confidence: 99%

Polymer‐based microparticles in tissue engineering and regenerative medicine

Oliveira

2011

Biotechnology Progress

149

105

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Different types of biomaterials, processed into different shapes, have been proposed as temporary support for cells in tissue engineering (TE) strategies. The manufacturing methods used in the production of particles in drug delivery strategies have been adapted for the development of microparticles in the fields of TE and regenerative medicine (RM). Microparticles have been applied as building blocks and matrices for the delivery of soluble factors, aiming for the construction of TE scaffolds, either by fusion giving rise to porous scaffolds or as injectable systems for in situ scaffold formation, avoiding complicated surgery procedures. More recently, organ printing strategies have been developed by the fusion of hydrogel particles with encapsulated cells, aiming the production of organs in in vitro conditions. Mesoscale self-assembly of hydrogel microblocks and the use of leachable particles in three-dimensional (3D) layer-by-layer (LbL) techniques have been suggested as well in recent works. Along with innovative applications, new perspectives are open for the use of these versatile structures, and different directions can still be followed to use all the potential that such systems can bring. This review focuses on polymeric microparticle processing techniques and overviews several examples and general concepts related to the use of these systems in TE and RE applications. The use of materials in the development of microparticles from research to clinical applications is also discussed.

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Section: Applications Of Microparticles In Tissue Engineering and Regmentioning

confidence: 99%

Polymer‐based microparticles in tissue engineering and regenerative medicine

Oliveira

2011

Biotechnology Progress

149

105

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“…In a pair of reports, the Gama group characterized the dextran-IL-10 nanogels and showed release of active IL-10 in biological relevant amounts for 4 hours in vivo [28,29]. Another report utilized intratracheal delivery for hydrogel-based therapies to administer basic Fibroblast Growth Factor to alleviate monocrotaline-induced pulmonary hypertension in rats [30].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice

et al. 2019

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Idiopathic pulmonary fibrosis (IPF) is a life-threatening progressive lung disorder with limited therapeutic options. While interleukin-10 (IL-10) is a potent anti-inflammatory and anti-fibrotic cytokine, its utility in treating lung fibrosis has been limited by its short half-life. We describe an innovative hydrogel-based approach to deliver recombinant IL-10 to the lung for the prevention and reversal of pulmonary fibrosis in a mouse model of bleomycin-induced lung injury. Our studies show that a hyaluronan and heparin-based hydrogel system locally delivers IL-10 by capitalizing on the ability of heparin to reversibly bind IL-10 without bleeding or other complications. This formulation is significantly more effective than soluble IL-10 for both preventing and reducing collagen deposition in the lung parenchyma after 7 days of intratracheal administration. The antifibrotic effect of IL-10 in this system is dependent on suppression of TGFβ driven collagen production by lung fibroblasts and myofibroblasts. We conclude that hydrogelbased delivery of IL-10 to the lung is a promising therapy for fibrotic lung disorders.

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“…The design of novel therapeutics to promote restorative angiogenesis engages bioengineering techniques to exploit biological pathways. Hydrogels are a class of hydrated, polymeric material that are widely used as artificial threedimensional scaffolds and as vehicles for drug delivery (19,20). Integrins are heterodimeric transmembrane receptors, composed of a and b subunits, which facilitate cellular adhesion between the extracellular matrix and cellular cytoskeleton.…”

Section: Et Al Hydrogels With Precisely Controlled Integrin Activmentioning

confidence: 99%

“…Segura's laboratory demonstrates the novel use of customized hydrogels with specific integrin activation modified by growth factors for angiogenic modulation after acute vascular injury. These customized hydrogels show promise as improved models of study to elucidate unknown pathophysiology of angiogenesis, as well as novel technology for drug delivery (20). Various types of hydrogels with different chemical and physical properties have been developed previously to improve localized delivery of growth factors for therapeutic angiogenesis (23).…”

Section: Et Al Hydrogels With Precisely Controlled Integrin Activmentioning

confidence: 99%

Developmental Origins of Chronic Lung Diseases. Mechanical Stretch, Micro-RNAs, and Hydrogels

McGraw

Sherlock

Bailey

2018

Am J Respir Cell Mol Biol

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Novel approach with intratracheal administration of microgelatin hydrogel microspheres incorporating basic fibroblast growth factor for rescue of rats with monocrotaline-induced pulmonary hypertension

Abstract: A single intratracheal administration of mGHMs/bFGF increased the number of vessels in the lung and ameliorated survival and hemodynamics in rats with monocrotaline-induced pulmonary hypertension.

Cited by 9 publications

References 22 publications

Polymer‐based microparticles in tissue engineering and regenerative medicine

Polymer‐based microparticles in tissue engineering and regenerative medicine

Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice

Developmental Origins of Chronic Lung Diseases. Mechanical Stretch, Micro-RNAs, and Hydrogels

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