Novel Approaches for The Construction of Cell Specific Surfaces using Heterobifunctinal Poly(ethylene glycol) (PEG).

Otsuka, Hidenori; Nakashima, Yoshikazu; Nagasaki, Yukio; Kato, Masaru; Kataoka, Kazunori

doi:10.2494/photopolymer.13.25

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…Instead of the noncovalent attachment of proteins, Otsuka et al [82,83] used immobilization with covalent chemical attachment. To achieve this, an acetal-terminated PEG-PLA diblock copolymer was synthesized that could be activated using acid to yield the amine-reactive aldehyde form (Figure 12d).…”

Section: Peg-aldehyde Tethersmentioning

confidence: 99%

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Teßmar

Göpferich

2007

Macromolecular Bioscience

190

132

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PEG-containing copolymers play a prominent role as biomaterials for different applications ranging from drug delivery to tissue engineering. These custom-designed materials offer enormous possibilities to change the overall characteristics of biomaterials by improving their biocompatibility and solubility, as well as their ability to crystallize in polymer blends and to resist protein adsorption. This article demonstrates various principles of PEG-based material design that are applied to fine tune the properties of biomaterials for different tissue engineering applications. More specifically, strategies are described to develop PEG copolymers with various block compositions and specific bulk properties, including low melting points and improved surface hydrophilicity. Highly hydrated polymer gel networks for promoting cellular growth or suppressing protein adsorption and cell adhesion are introduced. By incorporating selectively cleavable cross-links, these hydrophilic polymers can also serve as smart hydrogel scaffolds, mimicking the natural extracellular matrix for cell cultivation and tissue growth. Ultimately, these developments lead to the creation of biomimetic materials to immobilize bioactive compounds, allowing precise control of cellular adhesion and tissue growth. [image: see text]

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Section: Peg-aldehyde Tethersmentioning

confidence: 99%

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Teßmar

Göpferich

2007

Macromolecular Bioscience

190

132

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“…Primary methods of surface modification are alkaline etching or copolymerization with more hydrophilic monomers . Attempts have been made to increase the hydrophilicity by blending, copolymerizing, coating, and grafting hydrophilic substances − . Surface hydrolysis can also improve the hydrophilicity of PLLA .…”

Section: Introductionmentioning

confidence: 99%

Alkali Etching of a Poly(lactide) Fiber

Sun

Wei

Olson

et al. 2009

ACS Appl. Mater. Interfaces

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Alkali etching of a poly(l-lactic acid) fiber was studied by exposing the fiber surface to sodium hydroxide solutions. The factors examined included the etching time (0-1.5 h), alkali concentration (0.25-3 mol/L), and etching temperature (25-80 degrees C). The extent of etching was determined gravimetrically. Both weight loss and mechanical testing results suggest that alkali etching is strictly a surface hydrolysis reaction, as opposed to a bulk reaction, and thus the weight loss rate decreases with a shrinking fiber radius. A slight increase in the fiber crystallinity observed from thermal analysis was interpreted as a result of surface-limited etching on a sheath-core fiber microstructure. The dependence of the rate on the alkali concentration is nonlinear, suggesting that the fiber weight loss rate is subject to both chemical hydrolysis and transport limitations. The dependence of the rate on the temperature follows the Arrhenius equation. The fiber weight after etching can thus be predicted by an overall expression combining all factors: time, temperature, concentration, and fiber diameter.

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“…It is wellknown that the component of a low surface free energy in multicomponent polymeric systems is preferentially concentrated at the air surface region in order to minimize the air/ material interfacial free energy. The most common techniques to modify the surface properties of polymeric materials include blending, 14 copolymerization, 15 grafting, 16 coating, and plasma treatment. Although blending, copolymerization, and grafting are attractive methods to modify surface properties of PLLA, these methods also cause radical changes in the bulk properties, such as melting temperature and crystallinity of PLLA.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Solid-State Structure, and Surface Properties of End-Capped Poly(l-lactide)

et al. 2004

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End-capped poly(L-lactide) (PLLA) samples with dodecyl or 2-(2-(2-methoxyethoxy)ethoxy)ethyl (MEEE) ester were synthesized by ring-opening polymerization of L-lactide in the presence of zinc dodecanoxide or zinc 2-(2-(2-methoxyethoxy)ethoxy)ethoxide as a catalyst, respectively. On the basis of NMR analysis, it was confirmed that the carboxylic acid chain ends of PLLA molecules were selectively substituted by dodecyl or MEEE ester groups. To evaluate the wettability on the surface of end-capped PLLA films, the advancing contact angle (thetaa) with water was measured. The amorphous PLLA films showed relatively similar thetaa values regardless of the chemical structure of the polymer chain end. In contrast, the thetaa values of semicrystalline films were varied over a wide range, dependent on the chemical structure of the chain end. In addition, the thetaa values of dodecyl ester end-capped PLLA film with low molecular weight increased with an increase in the crystallization temperature. Both the crystallinity and lamellar thickness of dodecyl ester end-capped PLLA films increased with the crystallization temperature. These results suggest that the segregation of the chain ends on the PLLA film surface was strongly affected by the crystallization conditions.

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Novel Approaches for The Construction of Cell Specific Surfaces using Heterobifunctinal Poly(ethylene glycol) (PEG).

Cited by 6 publications

References 10 publications

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Customized PEG‐Derived Copolymers for Tissue‐Engineering Applications

Alkali Etching of a Poly(lactide) Fiber

Synthesis, Solid-State Structure, and Surface Properties of End-Capped Poly(l-lactide)

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