2020
DOI: 10.1177/0963689720926154
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Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

Abstract: Ovarian insufficiency is described as a multifaceted issue typically encountered in the field of assisted reproduction. The three main identified diagnoses of ovarian insufficiency include premature ovarian failure (POF), poor ovarian response (POR), and advanced maternal age (AMA). Patient heterogeneity in the era of individualized medicine drives research forward leading to the emergence of novel approaches. This plethora of innovative treatments in the service of adequately managing ovarian insufficiency is… Show more

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Cited by 20 publications
(10 citation statements)
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“…The prospective pilot study by Sfakianoudis et al (2020b ) determined that perimenopausal women and women deemed to be POR benefitted the most from the treatment, more so than POI and menopausal patients. In an article by Sfakianoudis et al (2020a ), they describe how novel techniques (such as PRP, ovarian stem cells transplant and ovarian tissue transplant) may effectively treat ovarian insufficiency by reactivating follicular growth through restoring the microenvironment of the ovary. Therefore, it should be acknowledged that PRP infusion may only be an appropriate treatment for select ovarian disorders.…”
Section: How Might Prp Induce Ovarian Rejuvenation?mentioning
confidence: 99%
“…The prospective pilot study by Sfakianoudis et al (2020b ) determined that perimenopausal women and women deemed to be POR benefitted the most from the treatment, more so than POI and menopausal patients. In an article by Sfakianoudis et al (2020a ), they describe how novel techniques (such as PRP, ovarian stem cells transplant and ovarian tissue transplant) may effectively treat ovarian insufficiency by reactivating follicular growth through restoring the microenvironment of the ovary. Therefore, it should be acknowledged that PRP infusion may only be an appropriate treatment for select ovarian disorders.…”
Section: How Might Prp Induce Ovarian Rejuvenation?mentioning
confidence: 99%
“…The arti cial ovary is also a promising alternative that will be used in in vitro growth and maturation approaches or to improve ovarian transplant in the future. Although it has been applied successfully in animal models, its e cacy and safety have to be proven before it is clinically used for patients [55].…”
Section: Discussionmentioning
confidence: 99%
“…Artificial ovary is also a promising alternative that will be used to in vitro growth and maturation approaches or to improve ovarian transplant in the future. Although it has been applied successfully in animal models, its efficacy and safety have to be proved before it becomes a reality for patients ( 45 ).…”
Section: Novel Strategies For Poi Managementmentioning
confidence: 99%
“…Another strategy, closely related to the previous one, is the generation of artificial gametes in patients who are not able to produce functional gametes. Artificial gametes could be generated from induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs) derived from blastocysts inner cell mass, or the putative germline stem cells (GSCs) ( 45 ). In animals, artificial gametes have been generated from GSCs ( 46 ), ESCs ( 47 ), and iPSCs ( 48 , 49 ).…”
Section: Novel Strategies For Poi Managementmentioning
confidence: 99%