Novel approaches in GVHD therapy

Svennilson, Johan

doi:10.1038/sj.bmt.1704850

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Specifically, stromal layers containing donor-type cells were observed in 14 out of 41 patients in one study (Cilloni et al, 2000) and 4 out of 14 patients in another study (Tanaka et al, 1994). (For a more detailed examination of MSC engraftment following bone marrow transplantation, please see Koc and Lazarus [2001], Rombouts and Ploemacher [2003], and Svennilson [2005].) In another study of significant interest, MSCs from eGFP transgenic mice were isolated from the BM, expanded in vitro, and systemically infused into wildtype mice (Belema-Bedada et al, 2008).…”

Section: Characterization Of Mscs Postdeliverymentioning

confidence: 99%

Mesenchymal Stem Cell Homing: The Devil Is in the Details

2009

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The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of methods used to assess homing events. This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues.

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Section: Characterization Of Mscs Postdeliverymentioning

confidence: 99%

Mesenchymal Stem Cell Homing: The Devil Is in the Details

2009

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“…Further trials need to be conducted before acceptance of these newer therapies. 12 Despite medical therapy, some patients may develop severe complications as a result of GVHD. Severe GI complications include small bowel perforation, obstruction, and GI hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Colonic Perforation in Graft Versus Host Disease: A Case Report

Palaniappa

Doyon²,

Divino³

2012

Int Surg

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Graft versus host disease (GVHD) is a phenomenon that occurs after allogeneic bone marrow transplants. Gastrointestinal (GI) manifestations of acute GVHD are common, but severe GI GVHD complications, such as bowel perforation, occur rarely and necessitate surgical intervention. To our knowledge, there are no recorded cases of colonic perforation resulting from GVHD with negative cultures for infectious agents such as cytomegalovirus. We present a case of large bowel perforation due to GVHD.Key words: Graft versus host disease -Autoimmune response -Large bowel -Bone marrow transplantation -Colonic perforation A lthough graft versus host disease (GVHD) is a common phenomenon after allogeneic bone marrow transplantation, it infrequently results in severe gastrointestinal (GI) complications that require surgical intervention such as small bowel perforation, obstruction, and GI hemorrhage. At present no cases of colonic perforation resulting from GVHD have been reported. We report a case of large bowel perforation resulting from GVHD after allogeneic bone marrow transplantation. Case ReportWe report the case of a 63-year-old man with chronic lymphocytic leukemia who received an HLA-matched unrelated stem cell transplant, followed by standard immunosuppression, antibiotic prophylaxis, and filgrastim (Neupogen). About 1 month later, he developed a diffuse erythematous rash consistent with GVHD grade III, as well as new onset diarrhea. Although the skin rash responded well to immunosuppresives, the diarrhea continued to worsen. Colonoscopy findings were suspicious for severe GVHD. The mucosa of the right and transverse colon had moderate-to-severe inflammatory changes, friability, and patchy dark exudates. This was confirmed with pathologic analysis that revealed diffuse crypt dropout and mucosal erosion.Despite total parenteral nutrition and maximal medical therapy, the diarrhea continued to progress. After several weeks, he had acute development of abdominal pain, distension, and tenderness to palpation, as well as fever and tachycardia. Pneumoperitoneum was present on computed tomography

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“…Methods: We hypothesized that an established therapy for CTCL which is anti-neoplastic and also immunomodulatory such as bexarotene and systemic PUVA (Stadler, et al 2009, Talpur, et al 2002 combined with DLI administration would represent an promising bimodal immunologic approach in the post-allo setting: On the one hand, enhanced graft-vs.-lymphoma activity resulting from systemic PUVA and bexarotene treatment would induce apoptosis of tumour cells which in turn increase tumour-antigen stimulation of the transferred donor lymphocytes. On the other hand, the risk of acute GvHD would be reduced by systemic PUVA and bexarotene (Schlaak, et al 2010, Svennilson 2005. Results: Here, we report the case of a patient with early (day +95) relapsed primary cutaneous T cell lymphoma in tumor stage after allogeneic stem cell transplantation who was successfully treated with a parallel administration of donor lymphocyte infusions (DLI) and systemic PUVA and bexarotene which led to sustained complete remission without onset of acute GvHD.…”

Section: Department Of Dermatology Hildesheim Germanymentioning

confidence: 99%

Poster Presentations

2011

J Deutsche Derma Gesell

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Novel approaches in GVHD therapy

Cited by 9 publications

References 19 publications

Mesenchymal Stem Cell Homing: The Devil Is in the Details

Mesenchymal Stem Cell Homing: The Devil Is in the Details

Colonic Perforation in Graft Versus Host Disease: A Case Report

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