Novel atmospheric plasma enhanced chitosan nanofiber/gauze composite wound dressings

Abstract

Electrospun chitosan nanofibers were deposited onto atmospheric plasma treated cotton gauze to create a novel composite bandage with higher adhesion, better handling properties, enhanced bioactivity, and moisture management. Plasma treatment of the gauze substrate was performed to improve the durability of the nanofiber/gauze interface. The chitosan nanofibers were electrospun at 3–7% concentration in trifluoroacetic acid. The composite bandages were analyzed using peel, gelbo flex, antimicrobial assay, moisture vapor transmission rate, X‐ray photoelectron spectroscopy (XPS), absorbency, and air permeability tests. The peel test showed that plasma treatment of the substrate increased the adhesion between nanofiber layers and gauze substrate by up to four times. Atmospheric plasma pretreatment of the gauze fabric prior to electrospinning significantly reduced degradation of the nanofiber layer due to repetitive flexing. The chitosan nanofiber layer contributes significantly to the antimicrobial properties of the bandage. Air permeability and moisture vapor transport were reduced due to the presence of a nanofiber layer upon the substrate. XPS of the plasma treated cotton substrate showed formation of active sites on the surface, decrease in carbon content, and increase in oxygen content as compared to the untreated gauze. Deposition of chitosan nanofibers also increased the absorbency of gauze substrate. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Waterproof and Breathable Electrospun Nanofibrous Membranes

“…Besides, W&B nanofibrous membranes possessing 3D network structure with large surface area and high pore volume, present high capacity of drug loading and sustained release, which are applicable to functional wound dressing material with tunable drug release properties . Shi et al .…”

“…Besides, W&B nanofibrous membranes possessing 3D network structure with large surface area and high pore volume, present high capacity of drug loading and sustained release, which are applicable to functional wound dressing material with tunable drug release properties. [142,143] Shi et al [144] performed electrospun nanofiber-based drug delivery system into wound dressing through constructing Janus membranes with the combination of hydrophobic polyacrylate (HPSA) nanofibers and hydrophilic cross-linked PVA (c-PVA) nanofibers, where the HPSA nanofibers were loaded with 5% ibuprofen as a model drug (Figure 11b). The composite membranes exhibited high breathability, mono-directional water penetration (Figure 11c,d), a sustained release manner for 48 h as well as excellent cumulative release.…”

Chitosan hydrogel‐coated cotton fabric: Antibacterial, pH‐responsiveness, and physical properties

“…It is a biocompatible polymer exhibiting a great variety of useful biological properties such as anticholesteremic and ion sequestering actions . Also, chitosan inhibits the growth of a wide variety of bacteria and fungi, showing broad spectra of antibacterial activity, high killing rate, and low toxicity toward mammalian cells . Thanks to its positive charge, the degree of N ‐deacetylation, the mean polymerization degree, and the nature of chemical modifications are those properties which strongly influence the antimicrobial effectiveness of chitosan .…”

“…13 Also, chitosan inhibits the growth of a wide variety of bacteria and fungi, showing broad spectra of antibacterial activity, high killing rate, and low toxicity toward mammalian cells. [14][15][16] Thanks to its positive charge, the degree of N-deacetylation, the mean polymerization degree, and the nature of chemical modifications are those properties which strongly influence the antimicrobial effectiveness of chitosan. 15,17 Similarly, it has a typical pH-sensitive polymer with a pKa that has a value approximate to 6.3.…”

Exploration of nanofibrous coated webs for chemical and biological protection

“…Such set up consists of syringe and needle having limitations of practical application in terms of obtaining uniform quality webs, durability, lower specific strength and very lower throughput rate (0.1-1.0 mL/h) and that is also for applying either in sound absorbing materials, aerosol and water filtration, wound healing and biomedical fabrics [2, [9][10][13][14][15][16][17][18][19].…”