Novel axially symmetric and unsymmetric silicon(<scp>iv</scp>) phthalocyanines having anti-inflammatory groups: synthesis, characterization and their biological properties

Çelik, Gizem Gümüşgöz; Gonca, Serpil; Şahin, Belgin; Özdemir, Sadin; Atílla, Devrim; Gürek, Ayşe Gül

doi:10.1039/d2dt00652a

Cited by 10 publications

(8 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…studied the antioxidant properties of some symmetric and unsymmetric silicon(IV) phthalocyanines bearing meloxicam or triethylene glycol monomethyl groups on axial positions. The compounds exhibited high superoxide radical scavenging activities [66] . The antioxidant features of compounds SiPcQ1 – 3 were in agreement with our previous achievements and literature.…”

Section: Resultssupporting

confidence: 90%

“…The compounds exhibited high superoxide radical scavenging activities. [66] The antioxidant features of compounds SiPcQ1-3 were in agreement with our previous achievements and literature. They can be used as antioxidant substances after further investigations.…”

Section: Chemistryselectsupporting

confidence: 90%

“…The results were visualized by applying the BioRad Gel Doc XR system. [81] Topoisomerase-I enzym inhibition assay: The human DNA topoisomerase I inhibition assay was performed according to the method has been described in the literature [66]. In the relaxation method, buffer (10xTGS), pBR322 supercoiled plasmid DNA (100 μg), 1 unit of DNA topoisomerase I enzyme, and different concentrations of compounds (SiPcQ1-3) ranging from 50 μM to 200 μM were added and the final volume was reached by adding distilled water.…”

Section: Pharmacological/biological Assaysmentioning

confidence: 99%

See 2 more Smart Citations

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Yenilmez¹,

Farajzadeh²,

Tollu³

et al. 2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

This study reports the synthesis of three silicon phthalocyanines (SiPc1–3) bearing 2‐dimethylaminoethoxy, 2‐[2‐(dimethylamino)ethoxy]ethoxy, or 2‐{2‐[2‐(dimethylamino)ethoxy]ethoxy}ethoxy on axial positions. Also, their quaternized derivatives (SiPcQ1–3) were prepared. The effect of ligand length on the biological features of water‐soluble silicon phthalocyanines (SiPcQ1–3) was investigated. The highest antimicrobial activity was obtained 32 μg/mL for SiPcQ1 against double‐distilled water, E. hirae, and E. faecalis. The growth inhibition percentages of compounds SiPcQ1–3 were obtained 100 %, 100 %, and 85.14 %, respectively. The highest biofilm inhibition activity was obtained 86.16 % for 250 mg/L SiPcQ3 against S. aureus. The E. coli growth inhibition activities of 50 mg/L compounds SiPcQ1–3 ranged from 60.17 % to 87.53 % and their activities increased (73.46 %–95.37 %) by the enhancement of the concentration. The E. coli viability inhibition activities of SiPcQ1–3 were concentration‐dependent. The DNA cleavage and binding properties of SiPcQ1–3 were studied using pBR322 DNA and CT‐DNA, respectively. Besides, the toxicity of SiPcQ1–3 was examined against the human colon cancer cell line (DLD‐1). The IC50 values of compounds (SiPcQ1–3) were obtained between 10.12 and 27.06 μM in the dark, however, these values were calculated between 12.32 and 22.17 μM under the light. SiPcQ3 exhibited the highest in vitro anticancer activity against the tested cell.

show abstract

Section: Resultssupporting

confidence: 90%

Section: Chemistryselectsupporting

confidence: 90%

Section: Pharmacological/biological Assaysmentioning

confidence: 99%

See 1 more Smart Citation

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Yenilmez¹,

Farajzadeh²,

Tollu³

et al. 2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

show abstract

“…Symmetric silicon phthalocyanines bearing diclofenac groups in the axial positions displayed higher antioxidant activity. 66 Compared with the literature, the nanoconjugates ( Au-Pc1-6 ) exhibited high antioxidant activities and can be used as suitable antioxidants after further investigations.…”

Section: Resultsmentioning

confidence: 88%

“…Compared to the literature, all the studied nanoconjugates exhibited acceptable DNA cleavage activities. 66 Fig. 2 The general antioxidant activity of nanoconjugates (Au-Pc1-6).…”

Section: Dna Cleavage Studiesmentioning

confidence: 99%

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

et al. 2023

View full text Add to dashboard Cite

show abstract

Investigation of advanced biological properties of carbon, carbon‐boron quantum dots, and copper (II) phthalocyanine nanoconjugates

Özçeşmeci,

Gümrükçü,

Ünlü

et al. 2024

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

Non‐peripherally, glycerol terminal groups substituted copper (II) phthalocyanine were non‐covalently (electrostatic and/or π–π interaction) attached to carbon (CQD) and carbon‐boron quantum dots (CBQD) to form QDs‐Pc nanoconjugate systems. Synthesized novel phthalocyanine compounds and QDs‐Pc conjugate systems were characterized using different spectroscopic techniques. Various biological assessments were applied to newly synthesized compounds. Conjugates 4 and 5 had a maximal free radical scavenging activity of 71.3% and 68.1% at a 100 mg/L concentration. Compounds exhibited high antidiabetic activities at 200 mg/L. Also, compounds showed significant DNA nuclease activity at all tested concentrations. The most efficient MIC value was obtained as 4 mg/L against Enterococcus hirae and Enterococcus feacalis. This MIC value was further decreased after photodynamic therapy, and it was observed that the antimicrobial effects of the compounds increased. Inhibition of microbial cell viability was obtained as 100% for all compounds. In addition, compounds exerted perfect biofilm inhibitory effects.

show abstract

Novel axially symmetric and unsymmetric silicon(iv) phthalocyanines having anti-inflammatory groups: synthesis, characterization and their biological properties

Cited by 10 publications

References 75 publications

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

Silicon Phthalocyanines as Anti‐infectious, Antioxidant, and Anticancer Agents

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

Investigation of advanced biological properties of carbon, carbon‐boron quantum dots, and copper (II) phthalocyanine nanoconjugates

Contact Info

Product

Resources

About