Novel Benzimidazole- Platinum(II) Complexes: Synthesis, Characterization, Antimicrobial and Anticancer Activity

Doğan, Umut; Özcan, Önder; Alaca, Gizem; Arı, Aydan; Günnaz, Salih; Yalçın, Hüsniye Tansel; Şahın, Onur; İrişli, Sevil

doi:10.1016/j.molstruc.2020.129785

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…In particular, complex 15 exhibited significantly higher selectivity for the U87 and SHSY-5Y lines in comparison to the reference (cisplatin). Disubstituted benzimidazole platinum derivatives have potential as a therapy against glioma and neuroblastoma cells [ 27 ].…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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“…Platinum compounds containing N-donor ligands such as benzimidazole show better biological efficiency with less toxicity (Al-Khathami et al, 2019;Facchetti & Rimoldi, 2019). According to literature data, benzimidazoles with substituents at the C2 position have activity a variety of cancer cell types (Gozelle et al, 2019;Nashaat et al, 2020;Doğan et al, 2021). Several platinum compounds bearing substituted benzimidazole ligands were reported previously (Zeyrek et al, 2017;Eren et al, 2018;Eren et al, 2019;Gozelle et al, 2019;Niknam et al, 2019;Özçelik et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-Substitutedbenzimidazolium Tetrachloroplatinate(II) Compounds and Their Cytotoxic Activities on Different Cell Lines

GÖZELLE¹,

Süloğlu

2022

Fabad J Pharm Sci

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The aim of the study was the synthesis of novel platinum compounds having benzimidazole ligands and screening for their in vitro cytotoxic activity on human cervical carcinoma HeLa, human lung carcinoma A549, and human lung epithelial Beas-2B cell lines. 2-Substituted benzimidazole ligands were synthesized by using appropriate aldehydes and o-phenylenediamine. Subsequently, 2-substituted benzimidazole ligands and potassium tetrachloroplatinate(II) (K2PtCl4) were used to synthesize 2-isopropylbenzimidazole tetrachloroplatinate(II) (K1) and 2-(1-methylpropyl)benzimidazole tetrachloroplatinate(II) monohydrate (K2). HRMS, IR, elemental analysis, 1H-NMR, and melting point were used to characterize the synthesized compounds. Cytotoxic activities against HeLa, A549, and Beas-2B cells after 48 h and 72 h incubation of the platinum compounds were investigated via MTT assay. Cisplatin and carboplatin were used as reference drugs. The cytotoxic activity results showed that K2 platinum compound displayed 53.42%±2.21 (at 160 μM) on HeLa, 88.16%±0.22 (at 160 μM) on A549 and 92.09%±0.57 (at 160 μM) on Beas-2B after 48 h incubation, K2 displayed 27.42%±2.03 (at 160 μM) on HeLa, 93.95%±0.53 (at 160 μM) on A549 and 91.99±0.22 (at 160 μM) on Beas-2B after 72 h incubation. Both of the platinum compounds have higher cell inhibitory effects than reference drug carboplatin after 48 h incubation for tested cells.

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