Novel bifurcation stents coated with bioabsorbable nanofibers with extended and controlled release of rosuvastatin and paclitaxel

Lee, Chen‐Hung; Hsieh, Ming‐Jer; Liu, Shou-Cheng; Chen, Jan‐Kan; Liu, Shih‐Jung; Wen, Ming‐Shien; Hung, Kuo‐Chun

doi:10.1016/j.msec.2018.02.027

Cited by 12 publications

(8 citation statements)

References 51 publications

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Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

“…It is in this regard that biocompatible, biodegradable polymers and metallic materials have attracted increased attention [32,84] (Table 2). Manufacturing methods include, but are not limited to, photochemical etching [85,86], helical coiling [87,88], braiding techniques [89][90][91], fluid dispensing [92], three-dimensional (3D) printing [93,94], electrospinning [95,96], hot extrusion [97], and selective laser melting [98]. Abbreviations: PLA-polylactic acid; PDLLA-poly-DL-lactic acid; PLLA-poly-L-lactic acid; PGA-polyglycolide; PDLGA-poly-DL-lactide-co-glycolide; PLGA-poly-lactic-co-glycolide; PCL-polycaprolactone; PLA/PCL-polylactic acid/polycaprolactone; PCpolycarbonates; AE21-magnesium alloy containing~2% aluminum and~1% rare earth metals; AE42-magnesium alloy containing~4% aluminum and~2% rare earth metals; WE43-magnesium alloy containing 4.2% yttrium, 2.4% neodymium, 0.6% cerium/lanthanum, and 0.5% zirconium; AZ31-magnesium alloy containing~3% aluminum and~1% zinc.…”

Section: Bioresorbable Stentsmentioning

confidence: 99%

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Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold.

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Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

Section: Bioresorbable Stentsmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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“…Lee et al produced novel bifurcation stents coated with bio-absorbable nanofibers loaded with rosuvastatin and paclitaxel. These stents show two different mechanisms: firstly, rosuvastatin decreased the platelet adhesion, while the paclitaxel acts by inhibiting SMC proliferation [ 42 ].…”

Section: Endothelial Stenosis and Thrombosismentioning

confidence: 99%

Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

Ataei

Roufogalis

Kesharwani

et al. 2021

Bioinorganic Chemistry and Applications

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Statins are a wide category of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor drugs extensively prescribed for hypercholesterolemia. In fact, many studies showed beneficial effects of these agents on a variety of related illnesses, which include increased atherosclerotic plaque stability, decreased proliferation of vascular smooth muscle, platelet aggregation, the dampening of vascular inflammation, and also anabolic effects on bone tissue. Therefore, these drugs are considered as pleiotropic agents having different clinical applications other than those for which they were initially developed. Controlled drug delivery is an efficient way of delivery in tissue engineering. Amongst different controlled release formulations, nanofibers are a novel, alternative, widely used agent because of their unique properties. These include their sustained release of drug, a high drug-loading capacity, flexible shapes with a high surface-to-volume ratio, and superior porosity. Electrospinning is an economic and a simple method employed to produce nanofibers. In this report, studies related to statin nanofiber applications have been reviewed and their results have been summarized. Four different applications of statin nanofibers have been reported, including bone generation, endothelial stenosis and thrombosis, peripheral nerve injury, and anti-inflammatory action. Studies carried out both in vitro and in vivo showed effectiveness of statins in bone healing, aneurysm, and the healing of sciatic nerve injury. In addition, statins showed apoptosis effects and anti-inflammatory effects, with dose-dependent reduction of IL-6 and dose-independent reduction of TNF-α. Despite these promising results, validation via clinical trials is yet to be performed. The scope of statins in their pleiotropic range of actions is still not completely explored, and studies are still needed to enlighten different useful aspects of such drugs.

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“…In addition, the in vivo rabbit model suggested a sustained and steady release of high concentrations of vancomycin for up to eight weeks after stent implantation. Others developed bioabsorbable bifurcation stents, consisting of a double-slit tubular main body and two spiral branches, which were coated with rosuvastatin and paclitaxel-loaded electrospun PLGA fibers [ 157 ]. Results suggested that rosuvastatin and paclitaxel achieved 100% cumulative release for up to 27 days and 70 days, respectively, with the ability to reduce platelet adhesion and promote proliferation of smooth muscle cells.…”

Section: Nanostructured Fiber Surfacesmentioning

confidence: 99%

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

et al. 2018

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Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.

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Novel bifurcation stents coated with bioabsorbable nanofibers with extended and controlled release of rosuvastatin and paclitaxel

Cited by 12 publications

References 51 publications

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications

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