Novel bio-based core-shell organic-inorganic nanohybrid from embedding aspartic acid-guanine ionic liquid on the hydroxylated nano silica surface (nano [(Asp-Gua) IL@PEG-SiO2]): A versatile nanostructure for the synthesis of bis(2,3-dihydroquinazolin-4(1H)-one) derivatives and tricarboxamides under green media

Recent Developments on Five-Component Reactions

“…The same group modified the reaction by using terephthaldialdehyde to replace p -phenylenediamine as a 2-centered reactant in the synthesis of 2,2′-(1,4-phenylene)bis(3-phenyl-2,3-dihydroquinazolin-4(1 H )-one) derivatives 80 ( Scheme 32 ) [ 47 ]. The Nikoofar group recently employed multi-layered nano [(Asp-Gua) IL@PEG-SiO 2 ] catalyst for the synthesis of bis(2-phenyl-2,3-dihydroquinazolin-4(1 H )-one) derivatives using p -phenylenediamine as a 2-centered reactant [ 19 ].…”

“…Amidation and sequential isomerization produce tricarboxamides 23. Nikoofar and co-workers embedded aspartic acid-guanine ionic liquid on the hydroxylated nano silica face for making a novel bio-based core-shell organic-inorganic nano catalyst (Asp-Gua) IL@PEG-SiO 2 , and employed it for the synthesis of tricarboxamide derivatives 23 using two equiv of aromatic amines and one equiv each of aromatic aldehydes, t-butyl isocyanide, and Meldrum's acid (Scheme 9) [19]. The reaction starts with the Knoevenagel condensation of Meldrum's acid and aldehydes to form α,β-unsaturated compounds 24.…”

“…terephthaldialdehyde to replace p-phenylenediamine as a 2-centered reactant in the synthesis of 2,2′-(1,4-phenylene)bis(3-phenyl-2,3-dihydroquinazolin-4(1H)-one) derivatives 80 (Scheme 32) [47]. The Nikoofar group recently employed multi-layered nano [(Asp-Gua) IL@PEG-SiO2] catalyst for the synthesis of bis(2-phenyl-2,3-dihydroquinazolin-4(1H)-one) derivatives using p-phenylenediamine as a 2-centered reactant [19]. The Mohammadi group developed a 6C5CR for the synthesis of novel bis[spiro(quinazoline-oxindole)] derivatives 81 using two equiv each of isatoic anhydride and isatins and one equiv of diamines under the catalysis of alum (KAl(SO4)2 • 12H2O) (Scheme 33) [48].…”

Magnetized inorganic–bioorganic nanohybrid [nano Fe3O4‐SiO2@Glu‐Cu (II)]: A novel nanostructure for the efficient solvent‐free synthesis of thiazolidin‐2‐imines

“…Some examples are degradation of organic dyes in the presence of Fe 3 O 4cellulose-copper nanocomposite, [27] developing a venlafaxine electrochemical sensor by the magnetic nanocomposite of cellulose nanocrystals with copper (Fe 3 O 4 @CNC/Cu), [28] preparation of xanthenes and 1,4-disubstituted-1,2,3-triazoles through the catalytic role of natural phosphate-supported Cu (II), [29] Fe 3 O 4 @SiO 2imine/phenoxy-Cu (II)-catalyzed synthesis of 2-amino-4H-chromens, [30] and the one-pot synthesis of several substituted 1H-tetrazoles reported by 1,4-dihydroxyanthraquinone-copper (II) supported on superparamagnetic Fe 3 O 4 @SiO 2 NPs (Fe 3 O 4 @SiO 2 -DAQ-Cu (II)). [31] In the following of our research propensity to prepare novel core-shell nanostructures in order to promote multicomponent transformations based on green chemistry, [32][33][34][35][36] here in, we reported a newly prepared nanosized multilayered hybrid from embedding glutamic acid on the silicated magnetite core followed by anchoring Cu (II) cation on the outer surface [nano Fe 3 O 4 -SiO 2 @Glu-Cu (II)]. The obtained nano inorganicbio-metallic hybrid characterized via Fourier-transform infrared (FT-IR), field-emission scanning electron microscopy (FESEM), energy dispersive X-ray analysis (EDAX), transmission electron microscopy (TEM), X-ray fluorescence (XRF), thermogravimetric analysis or derivative thermogravimetric (TGA/DTG), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) techniques.…”

“…In the following of our research propensity to prepare novel core‐shell nanostructures in order to promote multicomponent transformations based on green chemistry, [ 32–36 ] here in, we reported a newly prepared nanosized multilayered hybrid from embedding glutamic acid on the silicated magnetite core followed by anchoring Cu (II) cation on the outer surface [nano Fe 3 O 4 ‐SiO 2 @Glu‐Cu (II)]. The obtained nano inorganic‐bio‐metallic hybrid characterized via Fourier‐transform infrared (FT‐IR), field‐emission scanning electron microscopy (FESEM), energy dispersive X‐ray analysis (EDAX), transmission electron microscopy (TEM), X‐ray fluorescence (XRF), thermogravimetric analysis or derivative thermogravimetric (TGA/DTG), vibrating sample magnetometer (VSM), X‐ray photoelectron spectroscopy (XPS), and Brunauer–Emmett–Teller (BET) techniques.…”