Novel bioactive Co-based alloy/FA nanocomposite for dental applications

Fathi, Mohammadhossein; Ahmadian, Mehdi; Bahrami, M.

doi:10.4103/1735-3327.95232

Cited by 13 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Food and Drug Administration records, ~400,000 hip arthroplasty procedures are performed every year in the US alone (1). As metals and metal prosthesis exhibit remarkable stability and abrasion resistance, they have been widely used in surgeries involving joint replacement and bone damage repair (2). However, abrasion and invasion of the prosthesis have been demonstrated to release large amounts of metal particles and ions, with the major components being cobalt (Co) and chromium (Cr) particles (3).…”

Section: Introductionmentioning

confidence: 99%

Low doses of Co nanoparticles induce death and regulate osteogenic differentiation in MG-63 cells

Han

Fan

2017

Molecular Medicine Reports

View full text Add to dashboard Cite

The aim of the present study was to investigate the effects of cobalt nanoparticles (CoNPs) on the proliferation and differentiation of human osteoblasts in vitro, and to investigate the molecular mechanisms via which CoNPs affect proliferation and differentiation of osteoblasts. The MG‑63 human osteoblast cell line was treated with different concentrations of CoNPs for 12 to 48 h in vitro. At each time point, cell morphology was observed and an MTT assay was performed to assess cell viability. Alkaline phosphatase (ALP), osteocalcin (BGLAP), collagen I (COL I), osteoprotegerin (OPG) and receptor activator of nuclear factor κ‑B ligand mRNA expression levels, and ALP, BGLAP and COL protein expression levels, were assessed by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. The viability of MG‑63 cells decreased significantly after treatment with CoNPs. As CoNP concentration increased, a higher growth inhibition and cell death was observed. Compared with CoNPs, treatment with the same concentration of Co2+ may have a greater inhibitory effect on the growth of MG‑63 cells. CoNPs affected the mRNAs expression levels of ALP, BGLAP, COL I and OPG in MG‑63 cells, and reduced the protein expression levels of ALP, BGLAP and COL I. In conclusion, the present study demonstrated that CoNPs induce cytotoxic effects on MG‑63 cells by markedly reducing cell viability and inducing cell death at high concentrations. In addition, CoNPs may inhibit the function and differentiation of osteoblasts by affecting the mRNA and protein expression levels of associated genes. The results of the present study indicate that CoNPs may serve an important role in the aseptic loosening mechanism following total joint replacement surgery, particularly in situations where metal on metal prostheses are used. Further study into inhibiting this effect is required.

show abstract

Section: Introductionmentioning

confidence: 99%

Low doses of Co nanoparticles induce death and regulate osteogenic differentiation in MG-63 cells

Han

Fan

2017

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…In the last few years, nanotechnology has emerged as a novel approach which has triggered a new industrial revolution due to its wide range of practical applications. (1) In terms of vocabulary, nano means one billionth (9,10) and was taken from the Greek word meaning dwarf. (2) The field of dentistry has been involved in the introduction of nanotechnology to human life in the environmental and medical sciences sector.…”

Section: Methodsmentioning

confidence: 99%

“…(8) Fat'hi et al used nano-fluorapatite in cobalt-based alloys for applications in dentistry. (9) In their research, Farzanegan explored the orthodontic use of nanoparticles including silver, copper, and zinc to prevent white enamel lesions around braces, They added nanoparticles to mouthwash to prevent the formation of caries around the braces, and used molybdenum disulfide nanoparticles to decrease friction between the wire and braces. (1) They also showed that in all designs, the lack of appropriate tools, technologies, and experts in the field of nanotechnology was acutely felt.…”

mentioning

confidence: 99%

Identifying and Ranking the Factors Impacting the Utilization of Nanotechnology in Dentistry using the MCDM Fuzzy Approach

Sefat

Jalali

2016

3dj

View full text Add to dashboard Cite

One of the existing problems in the field of dentistry is the use of utilizing materials. Utilizing materials in dentistry must have high rigidity and resistance and a beautiful appearance. The weak formulation of dentistry materials causes irritation, side effects, and increases the cost of healthcare. Therefore, farms and organizations related to dentistry care are trying to produce highly efficient products. Therefore, in the current research, we attempted to recognize and rank the factors that impact on the utilization of nanotechnology in dentistry by an MCDM Fuzzy approach. The statistical community of the present research includes dentists and university experts, who are active in the field of Nano-Dentistry in Mazandaran, Dentist College in Sari. They are selected by the consensus of two groups. The first group included managers and superordinate experts of the organization with 32 people for localizing the modeling. In the second group, five experts as the statistical sample were selected.

show abstract

“…The bottles were kept in water bath (36.5±0.5 °C) for 3, 7, 14 and 28 days without changing SBF. At the end of each periods, one sample of each nanocomposites were rinsed with deionized water and dried at room temperature [31].…”

Section: In Vitro Assessment Of the Bioactivity Of Compositesmentioning

confidence: 99%

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Seyedmajidi¹,

Seyedmajidi²,

Alaghehmand³

et al. 2018

Eurasian J Anal Chem

View full text Add to dashboard Cite

The aim of this study was to synthesize and characterization of hydroxyapatite/bioactive glass (HA/BG) nanocomposite foam and fluorapatite/bioactive glass (FA/BG) nanocomposite foam by gel casting method as cell scaffold for bone tissue engineering and evaluating their bioactivity using in vitro methods. Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Archimedes method and universal testing machine were used in order to evaluate specific surface area, phase composition, shape, size and interconnectivity of pores, size and shape of the constructed foam particles, porosity measurement and compressive strength of prepared nanocomposite foams, respectively. Mean particle size of HA/BG and FA/BG nanocomposite foams were 78 and 42 nm respectively with average pore size ranges was from 100 to 400 µm for two compositions. The maximum values of compressive strength and elastic modulus of nanocomposite foams were 0.22 and 17.8 Mpa for HA/BG and 0.13 and 22 MPa for FA/BG, respectively. The mean values of the apparent and true porosity were calculated 31 and 78% for HA/BG and 42 and 77% for FA/BG, respectively. The results of in vitro immersion of foams in simulated body fluid (SBF) demonstrate the formation of apatite on the surface of foams that indicating their bioactivity. The prepared nanocomposite foams in this research are appropriate substitutes for the bone defects in tissue engineering due to their characteristics. Moreover, using gel casting method to introduce these bioceramics provides the possibility to construct foams by molding or 3D printing in a desired shapes in accordance to patient's needs with high dimensional accuracy.

show abstract

Novel bioactive Co-based alloy/FA nanocomposite for dental applications

Cited by 13 publications

References 19 publications

Low doses of Co nanoparticles induce death and regulate osteogenic differentiation in MG-63 cells

Low doses of Co nanoparticles induce death and regulate osteogenic differentiation in MG-63 cells

Identifying and Ranking the Factors Impacting the Utilization of Nanotechnology in Dentistry using the MCDM Fuzzy Approach

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

Contact Info

Product

Resources

About