Novel bioactive compounds from actinomycetes

Sanglier, Jean‐Jacques; Wellington, Elizabeth M. H.; Béhal, V.; Fiedler, Hans‐Peter; Ghorbel, Raoudha; Finance, C.; Hacene, M.; Kamoun, Amel; Kelly, Catherine T.; Mercer, Derry K.; Prinzis, S.; Trigo, C.

doi:10.1016/0923-2508(93)90071-9

Cited by 30 publications

(20 citation statements)

References 10 publications

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“…Members of the genus Streptomyces are well known as a rich source of antibiotics and other important novel metabolites, including antihelminthic agents, antitumour agents, antifungal agents and herbicides (Seto et al, 1989;Konishi et al, 1991;Sanglier et al, 1993;Baltz, 1998). Baltz in his publication in 1998 reviewed the wide variety of the natural and genetically modified secondary metabolites that are produced mainly as antibiotics by members of the genus Streptomyces.…”

Section: Introductionmentioning

confidence: 99%

The Streptomyces flora of Badia region of Jordan and its potential as a source of antibiotics active against antibiotic-resistant bacteria

Saadoun

Gharaibeh

2003

Journal of Arid Environments

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Section: Introductionmentioning

confidence: 99%

The Streptomyces flora of Badia region of Jordan and its potential as a source of antibiotics active against antibiotic-resistant bacteria

Saadoun

Gharaibeh

2003

Journal of Arid Environments

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“…are Gram‐positive bacteria isolated from several types of soils, including tropical forest, mud, cerrado and cave soils. They provide a valuable reservoir of secondary metabolites and enzymes (Sanglier et al. 1993) and, collectively, strains of the genus Streptomyces are responsible for producing about 85% of known antibiotics (Okami and Hotta 1988).…”

Section: Introductionmentioning

confidence: 99%

Protein synthesis inhibitory activity in culture filtrates from new strains of Streptomyces isolated from Brazilian tropical soils

Reis

Costa

Cavalcanti

et al. 2003

Lett Appl Microbiol

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Aims:To investigate the effect of the culture supernatants from three newly isolated Streptomyces strains, 221, 235 and 606 on eukaryotic cells. Methods and Results: Cell lines were treated with the culture filtrates and assayed for protein synthesis by metabolic labelling, followed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis. RNA synthesis was investigated by [5-3 H]uridine incorporation. The three culture filtrates presented a strong inhibitory activity, reducing total protein synthesis of different eukaryotic cell lines by more than 85%. No effect on cellular RNA synthesis was detected. The culture filtrates did not affect the growth of the prokaryotic cells tested. Conclusions: These new Streptomyces strains, recently isolated from Brazilian tropical soils, produce molecule(s) with inhibitory activity specific to eukaryote protein synthesis. Significance and Impact of the Study: Streptomyces strains 221, 235 and 606, probably representing new species, might produce new bioactive compound(s), and can be used as valuable tools to study the protein synthesis pathway in eukaryotes.

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“…They are a group of organisms widespread in nature, and play a significant role in the future of biotechnology, because of their importance as producers of vitamins, enzymes, antitumour agents, immunomodifying agents and mainly antibiotic compounds (Goodfellow et al, 1988;Demain, 1995). According to Sanglier et al (1993) between 1988 and 1992, more than a hundred new molecules from actinomycetes were discovered. Approximately, 75% of these originated from the Streptomyces genus and at least 5,000 documented bioactive compounds are known as being produced by this genus (Anderson and Wellington, 2001).…”

Section: Introductionmentioning

confidence: 99%

Melanin production from marine Streptomyces

Vasanthabharathi¹,

Lakshminarayanan²,

Jayalakshmi³

2011

Afr. J. Biotechnol.

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Melanin pigments are frequently used in medicine, food and cosmetic preparations. In this study, three strains among 21 Actinomycetes sp isolates produced a diffusible dark pigment on starch casein an agar medium which was water soluble. The pigment production was estimated using L-tyrosine as substrate. Among the strains, 3 (F1, F2, F3) were used for further analysis. Optimized culture condition for melanin production were; 1% of starch-best carbon source, 0.2% of soyabean-best nitrogen source, salinity-15 ppt, temperature-35°C, pH-7.0 and incubation time-168 h. Sugarcane waste was found to be the cheaper and best source for melanin production. Melanin also showed activity against potential pathogens. The maximum antimicrobial activity was observed with Escherichia coli (20 mm) and Lactobacilus vulgaris (20 mm). F1 strain producing melanin was taken for FT-IR analysis. The FT-IR result confirmed that it was melanin pigment. Therefore, this study proved that sugarcane waste can be used for the production of melanin and it (melanin) has potential anti-bacterial activity.

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Novel bioactive compounds from actinomycetes

Cited by 30 publications

References 10 publications

The Streptomyces flora of Badia region of Jordan and its potential as a source of antibiotics active against antibiotic-resistant bacteria

The Streptomyces flora of Badia region of Jordan and its potential as a source of antibiotics active against antibiotic-resistant bacteria

Protein synthesis inhibitory activity in culture filtrates from new strains of Streptomyces isolated from Brazilian tropical soils

Melanin production from marine Streptomyces

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