Novel bioactive hydrophobic gentamicin carriers for the treatment of intracellular bacterial infections

Imbuluzqueta, Edurne; Elizondo, Elisa; Gamazo, Carlos; Moreno-Calvo, Evelyn; Veciana, Jaume; Ventosa, Nora; Blanco-Prieto, María J.

doi:10.1016/j.actbio.2010.11.031

Cited by 61 publications

(57 citation statements)

References 48 publications

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“…Making a hydrophilic antibiotic less soluble can be a viable strategy to extend its release [51]. This phenomenon has been observed with local vancomycin release from a bone graft void filler [52]. The clinical form of vancomycin, vancomycin HCl, was exhausted from its bone graft depot within 2-3 weeks; whereas, release of the desalted form of vancomycin was extended to 7 weeks (unpublished data).…”

Section: Non-targeted Controlled Deliverymentioning

confidence: 99%

“…The clinical form of vancomycin, vancomycin HCl, was exhausted from its bone graft depot within 2-3 weeks; whereas, release of the desalted form of vancomycin was extended to 7 weeks (unpublished data). Gentamicin sodium bis(2-ethylhexyl)sulfosuccinate (AOT), a less soluble form of gentamicin, in PLGA nanoparticle showed release up to 70 days [52]. Other fatty acid derivatives of gentamicin such as gentamicin sodium dodecyl sulfate, gentamicin laurate and gentamicin palmitate also showed slower release from vascular prostheses [53].…”

Section: Non-targeted Controlled Deliverymentioning

confidence: 99%

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Novel drug delivery systems to combat antimicrobial resistance

Mulinti¹,

Hasan²,

Brooks³

2018

Fighting Antimicrobial Resistance

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Section: Non-targeted Controlled Deliverymentioning

confidence: 99%

Section: Non-targeted Controlled Deliverymentioning

confidence: 99%

Novel drug delivery systems to combat antimicrobial resistance

Mulinti¹,

Hasan²,

Brooks³

2018

Fighting Antimicrobial Resistance

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“…Besides, the low solubility of the gentamicin-AOT complex in aqueous environments could result in a slow diffusion of the drug through the polymeric matrix, and therefore, in a more sustained-release kinetic of the drug. 66 …”

Section: Antibiotic Materials Extended-release Dds P Gao Et Almentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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“…In the particles, the compounds of interest can be entrapped, chemically bound, absorbed in a biopolymer matrix or, in the particular case of the target element in a cavity surrounded by a coating (polymer membrane) encapsulated (López et al, 2012;Ranjit and Baquee, 2013). Among the biopolymers commercially available, poly(DL-lactideco-glycolide) (PLGA) -a biocompatible and biodegradable, US Food and Drug Administration (FDA)-approved polymer -has been widely used to protect active ingredients from harsh environments and improve their delivery and uptake (Anderson and Shive 1997;Astete and Sabliov, 2006) without affecting the interesting components' activity (Kalantarian et al, 2011;Imbuluzqueta et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Extract From Winery Industry Residue Using the Supercritical Anti-Solvent Technique

Mezzomo

Oliveira

Comim

et al. 2016

Braz. J. Chem. Eng.

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-Grape pomace (seed, skin and stem) is a winery byproduct with high levels of biologically active compounds, such as antioxidants and antimicrobials, that could be converted into high added-value products. Since these components are easily degraded by oxygen, light and high temperature exposure, stabilization is important, for instance, by a microencapsulation process. Therefore, the objective of this study was to investigate the influence on the particle characteristics of the operational conditions applied in the Supercritical Anti-Solvent (SAS) process for the co-precipitation of grape pomace extract and poly(-lactic-coglycolic acid) (PLGA). The morphology and size of the particles formed, their stability and thermal profile were evaluated, and also the co-precipitation efficiency. The conditions studied allowed the production of microparticles with spherical shape for all operational conditions, with estimated particle size between 4 ± 2 and 11 ± 5 µm, and very good co-precipitation efficiencies (up to 94.4 ± 0.6%). The co-precipitated extract presented higher stability compared to the crude extract, indicating the effectiveness of the co-precipitation process and coating material against degradation processes.

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Novel bioactive hydrophobic gentamicin carriers for the treatment of intracellular bacterial infections

Cited by 61 publications

References 48 publications

Novel drug delivery systems to combat antimicrobial resistance

Novel drug delivery systems to combat antimicrobial resistance

Recent advances in materials for extended-release antibiotic delivery system

Encapsulation of Extract From Winery Industry Residue Using the Supercritical Anti-Solvent Technique

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