Novel biochemical predictors of unfavorable prognosis for stable coronary disease

Cacko, Andrzej; Kondracka, Agnieszka; Gawałko, Monika; Główczyńska, Renata; Filipiak‬, Krzysztof J.; Bartoszewicz, Zbigniew; Opolski, Grzegorz; Grabowski, Marcin

doi:10.1097/md.0000000000012372

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…Apart from cTnI, the European Cardiology Society has endorsed both NT-proBNP and BNP to be assessed in patients with a history of ACS and in the management of heart failure 46 , 47 . Our results showed that NT-proBNP, the one with longer half-life and stability 48 , was markedly elevated in 5-FU-treated rats, demonstrating cardiomyocyte injury and stress.…”

Section: Discussionmentioning

confidence: 99%

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Muhammad

Sallam

El‐Abhar

2020

Sci Rep

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5-Fluorouracil (5-FU) is used in the treatment of different solid tumors; however, its use is associated with rare, but serious cardiotoxicity. Nevertheless, the involvement of ROCK/NF-κB, Akt/eNOS and ET-1/ERK1/2 trajectories in the cardiotoxic effect and in the potential cardioprotective upshot of simvastatin has been elusive. Male Wistar rats were allocated into 5-FU (50 mg/kg/week; i.p, 6 weeks), simvastatin (15 mg/kg/day; p.o, 8 weeks) treated groups and simvastatin + 5-FU, besides the normal control group. 5-FU-induced cardiotoxicity boosted the serum level of N-terminal pro-brain (B-type) natriuretic peptide (NT-proBNP), aortic contents of endothelin (ET)-1 and thromboxane (TX) A2, as well as cardiac contents of NADPH oxidases (Nox), cyclooxygenase (COX)-2, malondialdehyde (MDA), phosphorylated Akt (p-Akt), phosphorylated extracellular signal-regulated kinase (p-ERK)1/2 and the protein expressions of rho-kinase (ROCK) and caspase-3. On the other hand, it suppressed cardiac reduced glutathione (GSH) and phosphorylated endothelial nitric oxide synthase (p-eNOS). Contrariwise, co-administration with simvastatin overcame these disturbed events and modulated the ROCK/NF-κB, Akt/eNOS and ET-1/ERK1/2 signaling pathways. This study highlights other mechanisms than coronary artery spasm in the 5-FU cardiotoxicity and reveals that NT-proBNP is a potential early marker in this case. Moreover, the cross-talk between ROCK/ NF-κB, ROS/COX-2/TXA2, Akt/eNOS and ET-1/ERK1/2 pathways contributes via different means to upsetting the vasoconstriction/vasodilatation equilibrium as well as endothelial cell function and finally leads to cardiomyocyte stress and death—the modulation of these trajectories offers simvastatin its potential cardio-protection against 5-FU.

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Section: Discussionmentioning

confidence: 99%

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Muhammad

Sallam

El‐Abhar

2020

Sci Rep

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“…Among patients presenting with an acute coronary syndrome and undergoing coronary interventions, preprocedural C-reactive protein is an independent predictor of readmission to the hospital within 6 months of hospital discharge (10,22). Clearly, targeting in ammation as a way of improving outcomes in patients with cardiovascular diseases is an important initiative (14).…”

Section: Discussionmentioning

confidence: 99%

“…Although readmissions following vascular surgery are often unplanned (2,3), identi able clinical risk factors can be recognized at the time of discharge and include age, socioeconomic factors and select comorbidities (4)(5)(6)(7)(8)(9). There is emerging interest in exploring the utility of perioperative biomarkers as a means of predicting those patients who have the highest risk of adverse postoperative outcomes, including unplanned readmissions (10). Preoperative NT Pro-BNP has been recommended as an optimal means of risk-stratifying patients undergoing non-cardiac operations (11) and has been shown to have value in patients undergoing vascular surgery (12).…”

Section: Introductionmentioning

confidence: 99%

Preoperative C-Reactive Protein Levels Predict Readmission Following Elective Vascular Surgery

McFalls¹,

Khan²,

Dl³

et al. 2021

Preprint

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BackgroundC-reactive protein levels (CRP) may be reduced with long-term administration of ubiquinol (CoQ10) in patients with chronic ischemic heart disease but the impact of a short-term period of administration in patients undergoing elective vascular surgery is uncertain.MethodsA double-blind randomized controlled trial was implemented to determine whether preoperative administration of CoQ10 could reduce cardiac biomarker elevations. Patients were randomly assigned to CoQ10 (400 mg per day) versus Placebo for 3 days prior to surgery. BNP, troponin and CRP were obtained pre and post-surgery. The primary endpoint was peak BNP and secondary endpoints were length of stay and readmission.ResultsOne hundred and twenty-three patients were randomly assigned to CoQ10 (N=62) or Placebo (N=61) for 3 days pre-surgery. At 24 hours post-surgery, the group receiving CoQ10 had lower BNP levels with no intergroup differences in CRP. Within 1-year post-discharge, thirty-six (29%) were readmitted and preoperative risk for readmission (HR: 95% CI) included diabetes mellitus (3.60: 1.46-8.91), active smoking (3.55: 1.43-8.78) and CRP (1.35: 1.04-1.76). C-index for all three variables predicting readmission was 0.727. ConclusionsShort-term administration of CoQ10 reduced perioperative BNP but not CRP levels. CRP, along with diabetes and active smoking were independent predictors of readmission and should be targeted as a means of reducing subsequent rehospitalizations following elective vascular procedures.Trial Registrationclinicaltrials.gov Identifier: NCT03956017

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“…A number of prospective studies have consistently confirmed that a single hs-CRP measurement can independently predict vascular risk both in apparently healthy men and women that are asymptomatic for traditional risk factors of cardiovascular disease (CVD) [1,10]; and also predict risk of future coronary events in patients with acute coronary syndromes [11]. hs-CRP has been found to be the strongest predictor of coronary events compared to other novel biochemical [12] and traditional markers of CHD risks [13]. Studies have shown that there is a strong association between hs-CRP and other conditions that confers CVD risks such as metabolic syndrome, impaired glucose tolerance, type 2 diabetes mellitus and hypertension [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Association between High Sensitive-C Reactive Protein and Lipid Cardiovascular Risk Factors in Apparently Healthy Nigerian Young Adults

OO¹,

AA²

2019

IJDVR

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Background: CVD, in which coronary heart disease is the main manifestation, remains the major cause of morbidity and mortality worldwide. Chronic inflammatory process which starts from childhood tracking to adulthood has been reported to play a major role in the development and progression of atherogenesis leading to coronary heart disease. hs-CRP, an inflammatory marker has also been shown to best predict development of CVD even in the absence of traditional risk factors. Aim of this study is to ascertain hs-CRP as an independent risk factor as other lipid risk factors in young adults yet to develop CVD or other associated conditions. Methods: 150 age-matched healthy young adults were recruited into this cross-sectional study. They were grouped into three based on the level of hs-CRP; (Group A <3.0mg/L, Group B 3.0-10.0mg/L and Group C>10.0mg/L). Anthropometric measurement, plasma Total cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol, serum hs-CRP, Lipoprotein(a), Apolipoprotein A1, Apolipoprotein B and ApoB/A1 ratio were determined in the participants using standard methods. Results: There is a significant rising trend in weight, body mass index and waist-hip ratio in proportion to the increasing level of hs-CRP (p=0.021, p=0.004 and p=0.029 respectively). The HDL-cholesterol and ApoA1 levels significantly reduce in proportion to the rising levels of hs-CRP (p=0.000 and p=0.028 respectively). Also the total cholesterol correlates positively with hs-CRP(r=0.182, p=0.026), while a negative correlation exists between hs-CRP and HDL-cholesterol (r= -0.321, p=0.000) and ApoA1 (r= -0.246, p=0.002). Conclusions:This study has demonstrated that increase in central or visceral adiposity, plasma total cholesterol, triglycerides, ApoB; and decreases in plasma HDL-cholesterol and ApoA1, can invoke vascular inflammation which can be detected early by rising concentration of hs-CRP even in young individuals yet to develop CVD.

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Novel biochemical predictors of unfavorable prognosis for stable coronary disease

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 46 publications

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin

Preoperative C-Reactive Protein Levels Predict Readmission Following Elective Vascular Surgery

Association between High Sensitive-C Reactive Protein and Lipid Cardiovascular Risk Factors in Apparently Healthy Nigerian Young Adults

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