Novel biocompatible amide phthalocyanine for simultaneous electrochemical detection of adenine and guanine

Shantharaja,; Nemakal, Manjunatha; Kuntoji, Giddaerappa; Hegde, Subramanya; Sannegowda, Lokesh Koodlur

doi:10.1016/j.microc.2022.107223

Cited by 16 publications

(14 citation statements)

References 46 publications

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“…The HQCoPc/GCE electrode showed almost the same redox peak potential difference for the redox couple compared to pristine GCE with the increase in current density, which clearly infers that the synthesized HQCoPc actively mediates the charge-transfer process. However, the HQCoPc + KB/GCE composite electrode exhibited a higher current density with a larger Δ E value for the redox couple, confirming the faster charge-transfer kinetics for the Fe 2+/3+ redox couple at the HQCoPc + KB/GCE composite electrode and the higher activity is due to the presence of KB, which endows the composite with large surface area and high conductivity …”

Section: Resultsmentioning

confidence: 70%

Cobalt Phthalocyanine Based Metal–Organic Framework as an Efficient Bifunctional Electrocatalyst for Water Electrolysis

Giddaerappa,

Naseem Kousar,

Deshpande

et al. 2024

Energy Fuels

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Water is the most convenient and facile fossil-free source for the production of hydrogen (H 2 ). Electrochemical water splitting is considered a promising and potential approach for accomplishing hydrogen frugality. Although water-splitting reaction is the most versatile and green technique, it accounts for only 4% of the universal H 2 production. The main hindrance in large-scale production is the sluggish kinetics of the reaction, which employs costlier and precious catalysts. In addition, the half-cell reactions for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in water splitting require two different types of precious catalysts, which not only increases the cost but also decreases the efficiency due to the enhanced complexity of the system. Hence, designing an efficient, robust, nonprecious, earthabundant, and low-cost electrocatalyst capable of catalyzing both HER and OER during overall water splitting is an urgent requirement to meet the energy demand for sustainable growth. Here, a highly potential bifunctional electrocatalyst is fabricated using quinone-substituted cobalt(II) phthalocyanine (HQCoPc) with carbon nanoparticles (Ketjen black, KB). The organic hybrid of HQCoPc + KB modified on GCE and Ni foam showed remarkable electrocatalytic performance for HER and OER in acidic and basic conditions, respectively. The HQCoPc + KB composite affords a lower onset of 76 mV for HER and an overpotential of 234 and 360 mV at 10 mA•cm −2 for HER and OER, respectively, with superior stability for more than 40,000 s. The designed HQCoPc + KB bifunctional electrocatalyst not only offers a better catalyst for addressing a water-splitting reaction but also provides costeffectiveness and good chemical stability for sustainable energy technology.

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Section: Resultsmentioning

confidence: 70%

Cobalt Phthalocyanine Based Metal–Organic Framework as an Efficient Bifunctional Electrocatalyst for Water Electrolysis

Giddaerappa,

Naseem Kousar,

Deshpande

et al. 2024

Energy Fuels

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“…Immobilized on GCE, it demonstrated excellent performance with a low detection limit of 3 nM and high sensitivity of 2.99 µA•nM −1 •cm −2 , with a linear response range from 10 to 100 nM, showcasing potential applications in L-cysteine sensing as shown in Figure 11. Shantharaja et al [230] synthesized the novel pyrazolopyrimidinium analog bearing cobalt (II) phthalocyanine polymer (poly-CoTPzPyPc) and characterized its sensing ability for L-arginine. The polymer film displayed a linear response to L-arginine concentration in the range of 10-100 µM with a LOD of 2.5 µM.…”

Section: Amino Acid Biosensorsmentioning

confidence: 99%

“…Overcoming these obstacles leads to reliable, sensitive, and portable methods for amino acids detection. Copper-phthalocyanine molecule with amide linkages for simultaneous detection o adenine and guanine using an electrochemical method with improved sensitivity and superior detection for both nucleobases [228]. Hernández et al [242] successfully constructed a L-cysteine electrochemical sensor to assess L-cysteine levels in a complex embryo cell.…”

Section: Amino Acid Biosensorsmentioning

confidence: 99%

“…Due to their unique structural characteristics and superior optical qualities, Pc-and porphyrin-based aromatic macrocyclic compounds are useful as biosensor component material [53,54]. Their conjugated π-electron system [55] and planar structure allow for efficient electron transfer [56] and catalytic activity [57], which in turn allow for sensitive analyte detection [58]. Furthermore, macromolecules that provide tunable properties and biocompatibility [59,60], like polymers, dendrimers, calixarenes, and cyclodextrins, enable the selective immobilization of biomolecules and improve stability in biosensing applications [61,62].…”

Section: Introductionmentioning

confidence: 99%

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Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors to biomolecules, requiring adept conversion and amplification of interactions into various signal modalities like electrical, optical, gravimetric, and electrochemical outputs. Overcoming challenges associated with sensitivity, detection limits, response time, reproducibility, and stability is essential for efficient biosensor creation. The central aspect of the fabrication of any biosensor is focused towards forming an effective interface between the analyte electrode which significantly influences the overall biosensor quality. Polymers and macromolecular systems are favored for their distinct properties and versatile applications. Enhancing the properties and conductivity of these systems can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing a unique combination of attributes like advanced sensitivity, selectivity, thermal stability, mechanical flexibility, biocompatibility, and tunable electrical properties, emerge as promising candidates for biosensor applications. In addition, this approach enhances the electrochemical response, signal amplification, and stability of fabricated biosensors, contributing to their effectiveness. This review predominantly explores recent advancements in utilizing macrocyclic and macromolecular conjugated systems, such as phthalocyanines, porphyrins, polymers, etc. and their hybrids, with a specific focus on signal amplification in biosensors. It comprehensively covers synthetic strategies, properties, working mechanisms, and the potential of these systems for detecting biomolecules like glucose, hydrogen peroxide, uric acid, ascorbic acid, dopamine, cholesterol, amino acids, and cancer cells. Furthermore, this review delves into the progress made, elucidating the mechanisms responsible for signal amplification. The Conclusion addresses the challenges and future directions of macromolecule-based hybrids in biosensor applications, providing a concise overview of this evolving field. The narrative emphasizes the importance of biosensor technology advancement, illustrating the role of smart design and material enhancement in improving performance across various domains.

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“…Because mGO has compact dimensions and a high surface-to-volume ratio, most template molecules can easily access the imprinted binding sites, resulting in better binding and rebinding kinetics. 30 Adenine (Ad), one of the biological molecules that make up DNA, 31,32 is used as a template for recognizing Sus DNA, allowing the MIP composite to have a high selectivity due to its strong multisite interaction with the adenine nitrogenous base of Sus DNA. Furthermore, direct electrochemical detection of Sus DNA via the MIP composite generates electrochemical signals from the intrinsic electroactivity of DNA, avoiding the complex modification of the electrochemical reaction and the inefficient pre-immobilization method used in many DNA identification systems based on hybridization between probe DNA and its complementary sequence.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an imprinted polymer based graphene oxide composite for label-free electrochemical sensing of Sus DNA

et al. 2022

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Novel biocompatible amide phthalocyanine for simultaneous electrochemical detection of adenine and guanine

Cited by 16 publications

References 46 publications

Cobalt Phthalocyanine Based Metal–Organic Framework as an Efficient Bifunctional Electrocatalyst for Water Electrolysis

Cobalt Phthalocyanine Based Metal–Organic Framework as an Efficient Bifunctional Electrocatalyst for Water Electrolysis

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Fabrication of an imprinted polymer based graphene oxide composite for label-free electrochemical sensing of Sus DNA

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