Novel biocompatible and resorbable UV-transparent phosphate glass based optical fiber

Ceci-Ginistrelli, Edoardo; Pugliese, Diego; Boetti, Nadia Giovanna; Novajra, Giorgia; Ambrosone, Annarita; Lousteau, Joris; Vitale-Brovarone, C.; Abrate, S.; Milanese, Daniel

doi:10.1364/ome.6.002040

Cited by 62 publications

(111 citation statements)

References 35 publications

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“…The obtained attenuation loss values are in line with the typical values of phosphate glass optical fibers and with our previous experiments on resorbable CPG-based fibers [13,26,27] and can be mainly ascribed to the defects at the core/cladding interface of the fiber. Furthermore, these values are one up to two orders of magnitude lower in the decibel scale than those published so far for bioresorbable optical fibers, thus showing the advantage in using phosphate glass based optical waveguides for bioresorbable optics [7,9,10,14,15].…”

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confidence: 90%

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Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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confidence: 90%

“…A recent work by some of us proposed the employment of CPG as a new material for bioresorbable optical components [13]. They present a good biocompatibility without encountering the batch-to-batch variability that is typical of some biologically derived materials.…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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“…Phosphate glasses are of great interest for the manufacturing of photonic devices because of their good chemical stability, easy processing, high rare-earth solubility and excellent optical characteristics [1,2,3,4,5,6]. Due to these properties, phosphate glasses containing rare-earth (RE) ions are very attractive for optical communications [7], laser sources, as well as optical fiber amplifiers [8,9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Partial Crystallization on the Structural and Luminescence Properties of Er3+-Doped Phosphate Glasses

et al. 2017

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Er-doped phosphate glass ceramics were fabricated by melt-quenching technique followed by a heat treatment. The effect of the crystallization on the structural and luminescence properties of phosphate glasses containing Al2O3, TiO2, and ZnO was investigated. The morphological and structural properties of the glass ceramics were characterized by Field Emission-Scanning Electron Microscopy (FE-SEM), X-ray Diffraction (XRD), and micro-Raman spectroscopy. Additionally, the luminescence spectra and the lifetime values were measured in order to study the influence of the crystallization on the spectroscopic properties of the glasses. The volume ratio between the crystal and the glassy phases increased along with the duration of the heat treatment. The crystallization of the glass ceramics was confirmed by the presence of sharp peaks in the XRD patterns and different crystal phases were identified depending on the glass composition. Sr(PO3)2 crystals were found to precipitate in all the investigated glasses. As evidenced by the spectroscopic properties, the site of the Er3+ ions was not strongly affected by the heat treatment except for the fully crystallized glass ceramic which does not contain Al2O3, TiO2, and ZnO. An increase of the lifetime was also observed after the heat treatment of this glass. Therefore, we suspect that the Er3+ ions are incorporated in the precipitated crystals only in this glass ceramic.

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“…A new optical fiber made of this material recently has been manufactured using the thermal drawing technique [38]. Figure 2d presents a cross-section view of such a fiber.…”

Section: Materials and Synthesismentioning

confidence: 99%

Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

et al. 2018

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Optical fibers and waveguides in general effectively control and modulate light propagation, and these tools have been extensively used in communication, lighting and sensing. Recently, they have received increasing attention in biomedical applications. By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized. Therefore, implantable fibers and waveguides in biocompatible formats with versatile functionalities are highly desirable. In this review, we provide an overview of recent progress in the exploration of advanced optical fibers and waveguides for biomedical applications. Specifically, we highlight novel materials design and fabrication strategies to form implantable fibers and waveguides. Furthermore, their applications in various biomedical fields such as light therapy, optogenetics, fluorescence sensing and imaging are discussed. We believe that these newly developed fiber and waveguide based devices play a crucial role in advanced optical biointerfaces.

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Novel biocompatible and resorbable UV-transparent phosphate glass based optical fiber

Cited by 62 publications

References 35 publications

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Effect of Partial Crystallization on the Structural and Luminescence Properties of Er3+-Doped Phosphate Glasses

Biocompatible and Implantable Optical Fibers and Waveguides for Biomedicine

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