Novel Biological Activities of Allosamidins

Sakuda, Shohei; Inoue, Hiromasa; Nagasawa, Hiromichi

doi:10.3390/molecules18066952

Cited by 17 publications

(6 citation statements)

References 78 publications

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“…This appears particularly important for the bacterial growth in soil where chitin, mainly originating from insect cuticle and fungal cell walls, is a major nutrient source. Therefore, allosamidin is listed as a potent secondary metabolite with antifungal activity [ 180 ].…”

Section: Streptomycetes In Plant Protection Against Biotic Stressementioning

confidence: 99%

Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes

Vurukonda

Giovanardi

Stefani

2018

IJMS

481

252

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There has been many recent studies on the use of microbial antagonists to control diseases incited by soilborne and airborne plant pathogenic bacteria and fungi, in an attempt to replace existing methods of chemical control and avoid extensive use of fungicides, which often lead to resistance in plant pathogens. In agriculture, plant growth-promoting and biocontrol microorganisms have emerged as safe alternatives to chemical pesticides. Streptomyces spp. and their metabolites may have great potential as excellent agents for controlling various fungal and bacterial phytopathogens. Streptomycetes belong to the rhizosoil microbial communities and are efficient colonizers of plant tissues, from roots to the aerial parts. They are active producers of antibiotics and volatile organic compounds, both in soil and in planta, and this feature is helpful for identifying active antagonists of plant pathogens and can be used in several cropping systems as biocontrol agents. Additionally, their ability to promote plant growth has been demonstrated in a number of crops, thus inspiring the wide application of streptomycetes as biofertilizers to increase plant productivity. The present review highlights Streptomyces spp.-mediated functional traits, such as enhancement of plant growth and biocontrol of phytopathogens.

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Section: Streptomycetes In Plant Protection Against Biotic Stressementioning

confidence: 99%

Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes

Vurukonda

Giovanardi

Stefani

2018

IJMS

481

252

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“…A set of different molecules from Streptomyces spp. that act against insect pests have been found and characterized; these are, for instance, flavensomycin [194], antimycin A [195], piericidins [196], macrotetralides [197] and prasinons [198]. Streptomyces avermitilis, a common soil inhabitant, was shown to produce avermectins, molecules with potent activity against arthropods and nematodes [199].…”

Section: Streptomycetes In Plant Protection Against Biotic Stressesmentioning

confidence: 99%

Growth Promotion and Biocontrol Activity of Endophytic Streptomyces spp.

Vurukonda¹,

Giovanadri²,

Stefani³

2021

Prime Archives in Molecular Sciences

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The authors are thankful to CCS Aosta Srl, Quart (AO) for financial support of a Ph.D. grant devoted to study the role and use of Actinobacteria in agricultural systems (symbiotic agriculture). The authors kindly acknowledge the EU COST Action FA1103: -Endophytes in Biotechnology and Agriculture‖ (www.endophytes.eu) for providing an international network of scientists devoted to increase knowledge and use of endophytes in plant production.

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“…Allosamidin has a pseudotrisaccharide structure with a β-(1→4) disaccharide of AllNAc residues linked to a five-member cyclitol moiety fused to a dimethylaminooxazoline ring ( Figure 1 ). The fused five-member rings mimic the oxazolinium ion intermediate produced during the hydrolysis of insect family-18 chitinases [ 14 ]. Interestingly, mammals do not have chitin nor chitin synthase activities, but an acidic mammalian chitinase has been described.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Studies on the Incorporation of N-Acetylallosamine in Hyaluronic Acid-Inspired Thiodisaccharides

Cristófalo

Uhrig

2021

Molecules

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Two approaches for the synthesis of the thiodisaccharide β-S-GlcA(1→3)β-S-AllNAc are described here. The target disaccharide was a C-3 epimer and thio-analogue of the hyaluronic acid repetitive unit, tuned with a thiopropargyl anomeric group for further click conjugation. Thus, we analysed and tested two convenient sequences, combining the two key steps required to introduce the thioglycosidic bonds and consequently reach the target molecule: the SN2 substitution of a good leaving group (triflate) present at C-3 of a GlcNAc derivative and the introduction of the anomeric thiopropargyl substituent. The use of a 2-azido precursor showed to be a convenient substrate for the SN2 step. Nevertheless, further protecting group manipulation and the introduction of the thiopropargyl anomeric residue were then required. This approach showed to provide access to a variety of thiodisaccharide derivatives as interesting building blocks for the construction of neoglycoconjugates.

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Novel Biological Activities of Allosamidins

Cited by 17 publications

References 78 publications

Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes

Plant Growth Promoting and Biocontrol Activity of Streptomyces spp. as Endophytes

Growth Promotion and Biocontrol Activity of Endophytic Streptomyces spp.

Synthetic Studies on the Incorporation of N-Acetylallosamine in Hyaluronic Acid-Inspired Thiodisaccharides

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