Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines

Abstract

This manuscript described the synthesis and biological activity of novel nitro Also, fluorescence microscopy study showed cytoplasmic distribution of the compounds, demonstrating that DNA is not the primary target of compounds. Thus, considerable antiproliferative effects of studied compounds are due to interactions with other biological targets within cells.

Optical Sensing (Nano)Materials Based on Benzimidazole Derivatives

“…Heterocyclic chromophores and fluorophores are the most investigated classes of optical sensing molecules; hence, the interest for benzimidazole as a structural block of novel molecular systems is constantly increasing. Although benzimidazole derivatives are primarily known as biologically and therapeutically active substances [1], such heteroaromatic molecules have structure-related properties that enable a variety of applications in optoelectronics and non-linear optics (NLO) [2,3], photovoltaics [4,5], sensing [6] and bioimaging [7,8]. Indeed, multifunctionality of the benzimidazole unit, such as electron accepting ability, π-bridging, chromogenic pH sensitivity/switching and metal-ion chelating properties, makes it an exceptional structural candidate for the design of optical chemical sensors [9,10].…”

IND-2, a pyrimido[1″,2″:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells

“…Substituted 9-anilinothiazolo[5,4-b]quinolines ( Figure 1B ), which incorporate a quinoline scaffold fused with a thiazole ring, demonstrated cytotoxicity against four cancer cell lines [cervical (HeLa), colorectal (SW480 and SW620), and chronic myelogenous leukemia (K-562)] and also inhibited human topoisomerase II [12]. Annulation of the benzmidazole ring to the quinoline moiety resulted in cyclic benzimidazole[1,2-a]quinolines ( Figure 1B ) with antiproliferative effects on various cancer cells [13]. Some pyrimido[4’,5’:4,5]thieno(2,3-b)quinoline-4(3H)-ones ( Figure 1B ), with structural analogy to ellipticine, showed potent anti-leukemic activity in vitro and in vivo [14].…”

Recent Development of Benzimidazole‐Containing Antibacterial Agents

“…[36] In view of this, Garudachari et al [37] synthesized as eries of benzimidazole derivativesw ith as ubstituted quinolinen ucleus. [36] In view of this, Garudachari et al [37] synthesized as eries of benzimidazole derivativesw ith as ubstituted quinolinen ucleus.…”

“…Published reviewsh ave discussed the fact that benzimidazole derivatives with aq uinolone nucleus demonstrate superior pharmacological properties such as antimicrobial, antifungal, and antitumor activities. [36] In view of this, Garudachari et al [37] synthesized as eries of benzimidazole derivativesw ith as ubstituted quinolinen ucleus. The newly synthesized compounds weres creenedf or their antibacterial activities against E. coli, S. aureus, Xanthomonas spp.,a nd Salmonella spp.…”