Novel biomarkers associated with thoracic aortic disease

Thijssen, Carlijn G E; Dekker, Silvy; Bons, Lidia R.; Geenen, Laurie W; Gökalp, Arjen L.; Takkenberg, Johanna J.M.; Mokhles, Mostafa M; Bekkers, Jos A.; Boersma, Eric; Bouwens, Elke; Kimmenade, Roland R.J. van; Roos‐Hesselink, Jolien W.

doi:10.1016/j.ijcard.2023.02.006

Cited by 10 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study associated elevated levels of TLT-2 expressed in cells of the immune system [200] and IL-11 [226] with ATAAD. Yang et al, demonstrated an increase in C18-ceramide in ATAAD, suggesting its role in aortic inflammation via association with NLRP3 in the NLR family [228].…”

Section: Inflammationmentioning

confidence: 99%

“…It has been demonstrated that ECs derived from the aortic wall of an aneurysm present decreased levels of VE-cadherin, von Willebrand factor (vWF), and PECAM-1 [ 134 ]. These decreased levels disrupt mechanotransduction and induce macrophage infiltration in the media and adventitia through nuclear factor-kB NF-κB activation [ 190 , 200 ].…”

Section: Pathophysiologymentioning

confidence: 99%

“…MMPs have emerged as valuable circulating markers for ATAA pathology. Studies have highlighted the significance of circulating MMP-1 and MMP-2 [ 162 ], MMP-3 [ 200 ], and MMP-9 [ 117 ] as potential indicators in assessing and monitoring ATAA. Specifically, circulating MMP-3 and insulin-like growth factor binding protein 2 (IGFBP-2) have been associated with aortic diameter in patients with ATAA [ 200 ].…”

Section: Sporadic and Genetic Biomarkers In Ataa(d)mentioning

confidence: 99%

“…Studies have highlighted the significance of circulating MMP-1 and MMP-2 [ 162 ], MMP-3 [ 200 ], and MMP-9 [ 117 ] as potential indicators in assessing and monitoring ATAA. Specifically, circulating MMP-3 and insulin-like growth factor binding protein 2 (IGFBP-2) have been associated with aortic diameter in patients with ATAA [ 200 ]. Following the acute phase of aortic dissection, there is an increase in circulating MMP-9 levels, with plasma MMP-9 expression reaching its maximum approximately 2 weeks after the onset of symptoms [ 205 ].…”

Section: Sporadic and Genetic Biomarkers In Ataa(d)mentioning

confidence: 99%

“…The biomarkers that were found to be significantly associated with aortic size were primarily inflammatory markers IL-6 and GDF-15 [ 135 ]. Another study associated elevated levels of TLT-2 expressed in cells of the immune system [ 200 ] and IL-11[ 226 ] with ATAAD. Yang et al, demonstrated an increase in C18-ceramide in ATAAD, suggesting its role in aortic inflammation via association with NLRP3 in the NLR family [ 228 ].…”

Section: Sporadic and Genetic Biomarkers In Ataa(d)mentioning

confidence: 99%

See 4 more Smart Citations

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections

Ganizada,

Veltrop,

Akbulut

et al. 2024

Basic Res Cardiol

View full text Add to dashboard Cite

Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the risk of aortic wall dissection and rupture. Current management of aortic repair relies on an aortic diameter threshold. However, this approach underestimates the complexity of aortic wall disease due to important knowledge gaps in understanding its underlying pathologic mechanisms.Since traditional risk factors cannot explain the initiation and progression of ATAA leading to dissection, local vascular factors such as extracellular matrix (ECM) and vascular smooth muscle cells (VSMCs) might harbor targets for early diagnosis and intervention. Derived from diverse embryonic lineages, VSMCs exhibit varied responses to genetic abnormalities that regulate their contractility. The transition of VSMCs into different phenotypes is an adaptive response to stress stimuli such as hemodynamic changes resulting from cardiovascular disease, aging, lifestyle, and genetic predisposition. Upon longer exposure to stress stimuli, VSMC phenotypic switching can instigate pathologic remodeling that contributes to the pathogenesis of ATAA.This review aims to illuminate the current understanding of cellular and molecular characteristics associated with ATAA and dissection, emphasizing the need for a more nuanced comprehension of the impaired ECM–VSMC network.

show abstract

Section: Inflammationmentioning

confidence: 99%