Hepatitis B Virus and Liver Disease 2021
DOI: 10.1007/978-981-16-3615-8_10
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Novel Biomarkers for the Management of Chronic Hepatitis B Virus Infection

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“…Controversial issues regarding the treatment of chronic HBV infection include when to start anti-HBV therapy. [5,6] Solid evidence supports that patients with high serum HBV DNA liver ( ≥ 20,000 IU/mL for HBeAgpositive subjects and ≥ 2000 IU/mL for HBeAgnegative subjects) and active necroinflammatory activity of the liver (indicated by elevated serum alanine transaminase level ≥ 2 times upper limit of normal) should be considered for anti-HBV therapy. Patients with advanced fibrosis or established cirrhosis should also be given long-term anti-HBV therapy when their serum HBV DNA is detectable.…”
Section: Pros and Cons Of Expanding Treatment Indications In Patients...mentioning
confidence: 99%
“…Controversial issues regarding the treatment of chronic HBV infection include when to start anti-HBV therapy. [5,6] Solid evidence supports that patients with high serum HBV DNA liver ( ≥ 20,000 IU/mL for HBeAgpositive subjects and ≥ 2000 IU/mL for HBeAgnegative subjects) and active necroinflammatory activity of the liver (indicated by elevated serum alanine transaminase level ≥ 2 times upper limit of normal) should be considered for anti-HBV therapy. Patients with advanced fibrosis or established cirrhosis should also be given long-term anti-HBV therapy when their serum HBV DNA is detectable.…”
Section: Pros and Cons Of Expanding Treatment Indications In Patients...mentioning
confidence: 99%