Novel biomarkers of cardiometabolic risk are associated with plasma glucose within non-diabetic range. The Brazilian Longitudinal Study of Adult Health – ELSA-Brasil

Almeida-Pititto, Bianca de; Ribeiro-Filho, Fernando Flexa; Lotufo, Paulo A.; Ferreira, Sandra Roberta Gouvêa

doi:10.1016/j.diabres.2015.04.021

Cited by 14 publications

(11 citation statements)

References 44 publications

(46 reference statements)

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“…The progressive deterioration of traditional cardiovascular risk factors within near-normal values, in parallel with elevation of E-selectin concentration, could suggest the utility of this biomarker in identifying earlier abnormalities in cardiometabolic risk profile [ 10 ]. In previous cross-sectional study, our group reported a direct association of E-selectin and other inflammatory biomarkers with worsening of the glucose metabolism [ 32 ]. Although our study design precludes establishing cause-effect relationship, the observations of increasing frequencies of components of the metabolic syndrome across E-selectin tertiles are in agreement with this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Almeida-Pititto

Ribeiro-Filho

Bittencourt

et al. 2016

Diabetol Metab Syndr

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BackgroundThis cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health—ELSA-Brasil.MethodsA sample of 984 individuals from ELSA-Brasil (35–54 years) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories of coronary artery calcium (CAC) scores were evaluated across the tertiles by ANOVA or Chi-squared test. In linear regression models, associations of E-selectin levels with insulin resistance index, adjusted for age, sex and adiposity were tested.ResultsThe mean age of the participants was 45.8 (SD 4.9) years and 55 % were women. Mean values of age, anthropometric data, biochemical variables and inflammatory status increased across E-selectin tertiles. Also, a gradual deterioration of the cardiometabolic profile was reflected by increments in frequencies (95 % CI) of BMI ≥ 25 kg/m2 [53.7 % (48.5–58.8), 61.0 % (56.1–66.5) and 64.2 % (59.0–69.4), p = 0.019], hypertension [18.0 % (14.1–22.8), 19.8 % (15.4–24.6) and 24.8 % (20.4–29.9), p = 0.048], pre-diabetes [62.5 % (57.4–68.3), 63.1 % (58.4–69.6) and 73.8 % (68.8–78.3), p = 0.003] and hypertriglyceridemia [22.4 % (17.9–27.2), 27.3 % (22.5–32.8) and 33.4 % (28.3–38.5), p = 0.013]. Insulinemia and HOMA-IR were independently associated with E-selectin concentration. A greater proportion of individuals with CAC scores different from zero was found in the third tertile when compared with the first and second tertiles (16.1 versus 11 %, p = 0.04, respectively).ConclusionsDirect associations of E-selectin with traditional risk factors slightly above their normal ranges, components of the metabolic syndrome, insulin resistance and presence of CAC suggest that this biomarker may indicate an initial atherogenic process.

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Section: Discussionmentioning

confidence: 99%

Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Almeida-Pititto

Ribeiro-Filho

Bittencourt

et al. 2016

Diabetol Metab Syndr

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“…11,12 An objective of the ELSA-Brasil is to examine surrogates of CVD and novel biomarkers of atherosclerosis. 13 The ELSABrasil study group has already reported normal ranges for CIMT according to sex, age and race in a large Brazilian sample and an association of CIMT with body adiposity was found. 12,4 In the present analysis, we hypothesized that, independently of adiposity, the adiponectin concentration could help to identify subclinical atherosclerosis in ELSA-Brasil participants.…”

Section: Introductionmentioning

confidence: 99%

Association between carotid intima-media thickness and adiponectin in participants without diabetes or cardiovascular disease of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Almeida-Pititto

Ribeiro-Filho

Santos

et al. 2016

Eur J Prev Cardiolog

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Objective: The study assessed the association of adiponectin concentration with carotid intima-media thickness (CIMT) in middle-aged participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) without diabetes or cardiovascular disease. Design: Cross-sectional analyses. Methods: A sample of 687 individuals (35-54 years old) without diabetes or cardiovascular disease was stratified into two categories according to CIMT (< or ! 75th percentile). Traditional risk factors, C-reactive protein and adiponectin values were compared between categories by Student's t-test and frequencies by chi-square test. In linear regression models, associations of CIMT with adiponectin, adjusted for adiposity, blood pressure, C-reactive protein and homeostasis model assessment-insulin resistance were tested. Mean CIMT values were compared across quartiles of adiponectin concentrations using analysis of variance. Results: Three hundred and forty-one individuals (49.6%) were women and 130 (19.0%) had three traditional cardiovascular risk factors. Those with elevated CIMT (21.8%) had greater mean values of body mass index (26.2(3.8) vs. 27.7(4.0)kg/m 2 , p < 0.001), waist circumference (86.9(10.1) vs. 90.1(10.8) cm, p ¼ 0.001), systolic blood pressure (116.2(13.6) vs.121.2(16.1) mmHg, p < 0.001), homeostasis model assessment index (1.4(0.9-2.4) vs. 1.8(1.1-2.9), p ¼ 0.011), C-reactive protein (1.2 (0.6-2.6) vs. 1.4(0.8-3.2) mg/l, p ¼ 0.054) and adiponectin (9.9 (6.0-14.7) vs. 8.9 (5.3-13.8) mg/ml, p ¼ 0.002) levels than the counterpart, while plasma glucose and lipids were not different between groups. In the adjusted model, blood pressure (directly) and adiponectin (inversely) persisted associated with high CIMT. Mean CIMT was greater in the first quartile of adiponectin when compared with the other three quartiles (p ¼ 0.019). Conclusions: Lower adiponectin levels together with higher blood pressure were independently associated with elevated CIMT. Adiponectin concentration may be an independent marker of early structural damage in individuals at low-to-moderate cardiovascular risk.

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“…In cross-sectional studies of adults, higher levels of E-selectin and PAI-1 have been associated with impaired fasting glucose (IFG), impaired glucose tolerance, diabetes, and insulin resistance (Almeida-Pititto et al, 2015; Blüher et al, 2002; Kanaya et al, 2013; Thorand, Baumert, Döring, et al, 2006; Wang et al, 2010). In longitudinal studies, elevated levels of these biomarkers have been shown to precede the development of type 2 diabetes (Goldberg, 2009; Meigs et al, 2004; Thorand, Baumert, Chambless, et al, 2006) and its complications (Goldberg, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation may lead to endothelial dysfunction and a procoagulant state, both of which may contribute to the development of insulin resistance and atherosclerosis (Goldberg, 2009; Price & Loscalzo, 1999). In adults, higher levels of these biomarkers have been associated with hyperglycemia, insulin resistance, and diabetes (Almeida-Pititto, Ribeiro-Filho, Lotufo, Bensenor, & Ferreira, 2015; Blüher, Unger, Rassoul, Richter, & Paschke, 2002; Goldberg, 2009; Kanaya et al, 2013; Meigs, Hu, Rifai, & Manson, 2004; Mendivil, Robles-Osorio, Horton, Hamdy, & Caballero, 2013; Thorand, Baumert, Chambless, et al, 2006; Thorand, Baumert, Döring, et al, 2006; Wang, Liu, Wang, Tong, & Zhang, 2010). …”

Section: Introductionmentioning

confidence: 99%

Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Parrinello

Hua

Carnethon

et al. 2017

Journal of Diabetes and its Complications

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Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1,316 children 8–16 years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02 ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09] ). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

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Novel biomarkers of cardiometabolic risk are associated with plasma glucose within non-diabetic range. The Brazilian Longitudinal Study of Adult Health – ELSA-Brasil

Cited by 14 publications

References 44 publications

Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Association between carotid intima-media thickness and adiponectin in participants without diabetes or cardiovascular disease of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

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