The accumulation of ammonium (NH4+-N) and nitrous oxide (N2O-N) in the environment is causing concern due to their ecological impacts and contribution to global warming. Autotrophic nitrogen oxidizers, including aerobic ammonium-oxidizing archaea and bacteria, anaerobic ammonium oxidizer and nitrite oxidizers, play a crucial role in the nitrogen cycle by facilitating the removal of nitrogenous residues from the environment. Nitrogen oxides (NOx) like nitrite (NO2−-N) and nitrate (NO3−-N) are produced as key immediate products during the conversion of NH4+-N or N2O-N. Additionally, these autotrophic microbes utilize carbon dioxide (CO2) for cell synthesis, thereby mitigating the greenhouse effect. Preliminary results pointed out that nitrogen oxidizers could effectively remove NH4+-N and NOx from sewage and wastewater systems at the loading rate lower than 0.5 kg N/m3-day. Moreover, this family could also reduce the greenhouse N2O-N through oxidizing pathway, attaining the maximum reduction of 25.2-fold the annual N2O production.