Novel Blend for Producing Porous Chitosan-Based Films Suitable for Biomedical Applications

Abstract

In this work, a chitosan–gelatin–ferulic acid blend was used in different ratios for preparing novel films that can be used in biomedical applications. Both acetic and formic acid were tested as solvents for the chitosan–gelatin–ferulic acid blend. Glycerol was tested as a plasticizer. The thickness, mechanical strength, static water contact angle and water uptake of the prepared films were determined. Also, the prepared films were characterized using different analysis techniques such as Fourier transform infrared spectroscopy (FT-IR) analysis, X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Acetic acid produced continuous compact surfaces that are not recommended for testing in biomedical applications. The plasticized chitosan–gelatin–ferulic acid blend, using formic acid solvent, produced novel hexagonal porous films with a pore size of around 10–14 µm. This blend is recommended for preparing films (scaffolds) for testing in biomedical applications as it has the advantage of a decreased thickness.

Distilled pyroligneous liquor obtained from Eucalyptus grandis and chitosan: physicochemical properties of the solution and films

“…9) shows peaks at 2θ, 8.4-8.6, and 11.55°, located on a broad halo characteristic of amorphous materials. This result is similar to that found by Nady and Kandil (2018) for chitosan films diluted in acetic acid, confirming that chitosan is a semi-crystalline polysaccharide. The degree of crystallinity still depends on the degree of deacetylation of chitosan.…”

“…10). The micrographs show a homogeneous and compact structure similar to the data found in other works with this polymer (Liu et al 2013;Nady and Kandil 2018;Ocak 2018).…”

Advances in Drug Delivery via Biodegradable Ureteral Stent for the Treatment of Upper Tract Urothelial Carcinoma

“…Their own characteristics, such as biocompatibility, microstructure, mechanical strength, degradation rate, and the effect of antiinfection should be carefully considered in the design of BUS. It is fortunate that many natural origin polymers can meet these conditions and have been widely used in design of BUS (Auge et al, 2002;Nady and Kandil, 2018). Lingeman et al (2003) designed proprietary alginate polymer-based BUS and applied in 88 patients.…”

Halloysite Nanoclay/Biopolymers Composite Materials in Tissue Engineering

“…Biopolymers and their mixtures are among the most promising materials to be used in fabrication of tissue engineering constructs . Their mechanical properties can be modulated by mixing and forming porous structures, films with desired architectonics . Biopolymers such as collagen, fibrin, chitosan, agarose, silk, alginate, and also synthetic polymers are widely used for the fabrication of tissue engineering scaffolds …”