Novel cannabinoid release system: Encapsulation of a cannabidiol precursor into γ-cyclodextrin metal-organic frameworks

Rodríguez-Martínez, Jorge; Sánchez-Martín, María-Jesús; López-Patarroyo, Oscar; Valiente, Manuel

doi:10.1016/j.jddst.2022.104085

Cited by 8 publications

(4 citation statements)

References 46 publications

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“…A fast method using microwave irradiation was performed for γ-CD-MOF synthesis, and a cocrystallization method was used to load olivetol into these MOFs. This methodology has been described in a previous work [21]. DPPC liposomes were obtained by hydration and mechanical dispersion following a modified method previously described [15].…”

Section: Drug Delivery System Synthesismentioning

confidence: 99%

“…The quantification of the OLV content into the MOFs was performed following a methodology previously stablished [21]. For liposomes, the encapsulation of the drug was determined adapting a method previously described [7].…”

Section: Drug Release and Quantificationmentioning

confidence: 99%

“…Peaks were quite narrow for both potassium salts, indicating high crystallinity, especially when KNO 3 was employed since their peaks were sharper and more intense. These PXRD patterns have been already compared previously to the simulated references from the Crystalography Open Database (COD), including the JCPD card of the conventional CD-MOFs with the body-centered cubic space group I432 [21]. This recent publication showed the space group of these diffraction patterns matched with trigonal spaces groups when the metal linker was not delivered by potassium hydroxide [22].…”

Section: Drug Delivery Systems Characterization and Olivetol Quantifi...mentioning

confidence: 99%

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Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health

2023

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Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids. In vitro experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure. Graphical Abstract

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Section: Drug Delivery System Synthesismentioning

confidence: 99%

Section: Drug Release and Quantificationmentioning

confidence: 99%

Section: Drug Delivery Systems Characterization and Olivetol Quantifi...mentioning

confidence: 99%

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Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health

2023

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“…Although the synthesis of CD-MOFs using KCl or CH 3 COOK instead of KOH has been reported, in all cases reported so far, the synthesis takes a long time and/or requires additives to obtain the product. [34][35][36][37][38] Conventional synthesis methods invariably require a process to wash the products. In contrast, in our method, CD-MOFs can be synthesized in just over an hour.…”

mentioning

confidence: 99%