Novel Carbon-Based Magnetic Luminescent Nanocomposites for Multimodal Imaging

Abstract

Multifunctional nanocomposites can combine multiple functions into a single nanosystem and thus have attracted extensive interest in various fields. The combination of magnetic and upconversion luminescent nanoparticles into one single nanoplatform, which have a good application in biomedical fields such as bio-magnetic separation, magnetic resonance imaging (MRI), and optical imaging, is highly desirable. Here we reported multifunctional nanocomposites by using hollow carbon sphere to integrate magnetic Fe 3 O 4 and upconversion nanoparticles (UCNPs) into one nanosystem. The as-prepared UCNPs/Fe 3 O 4 @h-C have near-infrared (NIR) luminescence under 980 nm excitation and superparamagnetism. In addition, since the carbon layer can absorb NIR light and transfer it into heat with high efficiency, the nanocomposites can realize photo thermal (PT), upconversion luminescence (UCL) and MRI tri-mode imaging. The UCNPs/Fe 3 O 4 @h-C might be further utilized as a potential theranostic agent, including its in-depth monitoring through luminescent imaging and MRI diagnosis, as well as its direct use in tumors as a photothermal therapy (PTT) agent.

The Influence of Carbon Quantum Dots Addition on the Photoluminescence Performance of ZnO Nanoparticles

“…The performance of the bioimaging techniques relies on the use of probes with high specificity and sensitivity. Therefore, exploring materials with excellent photoluminescence properties and employing suitable strategies for their synthesis and application is necessary to analyze the biological microenvironment and related processes [6][7][8].…”

Multifunctional Superparticles for Magnetically Targeted NIR‐II Imaging and Photodynamic Therapy

“…[ 29 , 30 , 31 ] However, PDT meant for practical cancer treatment calls for not only real‐time imaging to track the distribution of nanoparticles in tumors but also tumor targeting ability to ensure high treatment efficacy and reduce side effects. [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ] Compared to conventional molecular modification‐based tumor targeting, physical interaction‐based magnetic targeting employs a magnetic field to attract magnetic nanoparticles that circulate in the blood to the tumor site where the magnet is placed, which avoids the specific receptor expression restriction and complex targeting molecule modification, indicating to be a more universal approach for tumor targeting. [ 40 , 41 , 42 , 43 ] To establish a PDT platform with effective tumor‐targeting efficacy, a composite consisting of UCNPs and Fe 3 O 4 has great potential.…”