2015
DOI: 10.1016/j.ajpath.2015.05.018
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Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-κB Regulation

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Cited by 25 publications
(17 citation statements)
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“…Targeted genetic analysis of all samples was undertaken using 454 pyrosequencing performed using the GS Junior system (Roche/454 Life Sciences, Branford, CT, United States) and Fluidigm (Fluidigm Corporation, San Francisco, CA, United States) PCR amplicon libraries as template. In addition to H, K , and NRAS , we also analyzed the genes NOTCH1, NOTCH2, TP53, CDKN2A, CARD11, CREBBP, TGFBR1 , and 2 , all of which our previous research has implicated in the pathogenesis of cSCC ( Brown et al, 2004 ; South et al, 2014 ; Cammareri et al, 2016 ; Watt et al, 2015 , 2016 ). Primers were designed and validated by Fluidigm (Fluidigm Corporation, San Francisco, CA, United States) as per recommended guidelines for Roche Titanium sequencing (Roche, Mannheim, Germany).…”
Section: Methodsmentioning
confidence: 99%
“…Targeted genetic analysis of all samples was undertaken using 454 pyrosequencing performed using the GS Junior system (Roche/454 Life Sciences, Branford, CT, United States) and Fluidigm (Fluidigm Corporation, San Francisco, CA, United States) PCR amplicon libraries as template. In addition to H, K , and NRAS , we also analyzed the genes NOTCH1, NOTCH2, TP53, CDKN2A, CARD11, CREBBP, TGFBR1 , and 2 , all of which our previous research has implicated in the pathogenesis of cSCC ( Brown et al, 2004 ; South et al, 2014 ; Cammareri et al, 2016 ; Watt et al, 2015 , 2016 ). Primers were designed and validated by Fluidigm (Fluidigm Corporation, San Francisco, CA, United States) as per recommended guidelines for Roche Titanium sequencing (Roche, Mannheim, Germany).…”
Section: Methodsmentioning
confidence: 99%
“…Although the functions of statin-related protein remain to be fully elucidated, an anti-inflammatory activity via tumor necrosis factor-α reduction has been reported for the statin-related rosuvastatin protein (39). CARD proteins are scaffold proteins that function as key regulators of NF-κB signaling by providing a link between membrane receptors and NF-κB transcriptional subunits (40). CARD11 and CARD14-mediated alterations in NF-κB signaling are thought to be an early event in the development of cutaneous squamous cell carcinoma and psoriasis, respectively (40,41).…”
Section: Discussionmentioning
confidence: 99%
“…CARD proteins are scaffold proteins that function as key regulators of NF-κB signaling by providing a link between membrane receptors and NF-κB transcriptional subunits (40). CARD11 and CARD14-mediated alterations in NF-κB signaling are thought to be an early event in the development of cutaneous squamous cell carcinoma and psoriasis, respectively (40,41). CARD9 in macrophages mediates necrotic smooth muscle cell-induced inflammation by activating NF-κB (42).…”
Section: Discussionmentioning
confidence: 99%
“…Further investigation of tumor antigens involved in cSCC pathogenesis is necessary, especially given that there is currently no targeted treatment option for cSCC widely in use [65]. Some cSCC tumor antigens in immunocompetent patients have been identified, such as mutated TP53 , HRAS , CDKN2A , PTCH, KNSTRN , CARD11 , NOTCH1 , and NOTCH2 gene products, overexpressed HER-2 , MUC-1 , EGFR, Fyn , and Ep-CAM gene products, as well as cancer-testis antigens [34,35,53,6568]. Additional tumor antigens in cSCC driver genes have been described among immunosuppressed patients, including FAT1 [69,70].…”
Section: Limitations and Future Workmentioning
confidence: 99%