2019
DOI: 10.1016/j.jcjo.2019.03.014
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Novel case of hybrid perineurioma-neurofibroma of the orbit

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Cited by 7 publications
(14 citation statements)
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“…1 The remaining one has components of perineurioma and neurofibroma. 2 Herein, we would like to share the first case of orbital tumor showing combined histomorphology of schwannoma and perineurioma.…”
Section: Orbital Hybrid Schwannoma/perineurioma: a Case Presentationmentioning
confidence: 99%
“…1 The remaining one has components of perineurioma and neurofibroma. 2 Herein, we would like to share the first case of orbital tumor showing combined histomorphology of schwannoma and perineurioma.…”
Section: Orbital Hybrid Schwannoma/perineurioma: a Case Presentationmentioning
confidence: 99%
“…This tumor is composed of a plexiform neurofibroma with areas of perineurial differentiation. 3 HPNSTs are extremely rare in the orbit, with 8 cases reported in the literature: 6 cases describe neurofibroma-schwannoma, 1 case describes a neurofibroma-perineurioma, and 1 case describes a schwannoma-perineurioma. 1,3,7,10,[14][15][16][17] The paucity of cases of HPNSTs in this region may be an underestimate, reflecting a lack of awareness of this relatively recently recognized entity.…”
Section: Discussionmentioning
confidence: 99%
“…3 HPNSTs are extremely rare in the orbit, with 8 cases reported in the literature: 6 cases describe neurofibroma-schwannoma, 1 case describes a neurofibroma-perineurioma, and 1 case describes a schwannoma-perineurioma. 1,3,7,10,[14][15][16][17] The paucity of cases of HPNSTs in this region may be an underestimate, reflecting a lack of awareness of this relatively recently recognized entity. Four previously reported patients were male and 4 were female, with an average age of 52 years (median 52.5, range 31-78).…”
Section: Discussionmentioning
confidence: 99%
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“…Ultrastructural studies showed that this tumor was composed of a mixture of three cell types: Schwann cells, perineural cells, and fibroblasts [ 7 , 16 ]. Immunohistochemistry showed immune reactivity in EMA and S100 protein (Figures 4(a) – 4(c) ) in perineurioma and neurofibroma, respectively [ 17 , 18 ]. Immunohistochemistry in our case was compatible with neurofibroma [ 15 ] ( Table 1 ).…”
Section: Discussionmentioning
confidence: 99%