2015
DOI: 10.3892/or.2015.4404
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Novel cellular and post-genomic technologies in the treatment of glioblastoma multiforme (Review)

Abstract: Glioblastoma multiforme (GBM) is one of the most aggressive brain tumors. The majority of modern treatment methods for GBM are not sufficiently effective with a median survival varying from 9 to 14 months. One of the main reasons for the therapeutic resistance of GBM is attributed to cancer stem cells. Pharmaceuticals that can effectively eliminate cancer stem cells do not exist. Experimentally, we have shown that cancer stem cells can be specifically affected to arrest adhesion, proliferation and migration, a… Show more

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Cited by 10 publications
(5 citation statements)
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“…ROS accumulation, disruption of the NADP/NADPH balance and abnormally high reduced glutathione (GSH)/glutathione disulfide (GSSG) ratios have been observed in several glioma cells and correlated with IDH mutations [11][12][13]. Astrocytoma is characterized by a high resistance to radiotherapy and chemotherapy treatments [14]. The alkylating agent temozolomide (TMZ) is currently used in standard chemotherapeutic treatment in addition to radiotherapy [15,16].…”
Section: Introductionmentioning
confidence: 99%
“…ROS accumulation, disruption of the NADP/NADPH balance and abnormally high reduced glutathione (GSH)/glutathione disulfide (GSSG) ratios have been observed in several glioma cells and correlated with IDH mutations [11][12][13]. Astrocytoma is characterized by a high resistance to radiotherapy and chemotherapy treatments [14]. The alkylating agent temozolomide (TMZ) is currently used in standard chemotherapeutic treatment in addition to radiotherapy [15,16].…”
Section: Introductionmentioning
confidence: 99%
“…More importantly, the incidence of glioblastoma multiforme is on a rise across the world [ 19 ]. With the increasing understanding of the molecular mechanisms of glioblastoma multiforme pathogenesis, reversion of the malignant phenotype of glioblastoma cells through targeted blockade of major signaling pathways involved in development, progression and chemotherapeutic resistance of glioblastoma multiforme has been paid much attention [ 20 , 21 ].…”
Section: Discussionmentioning
confidence: 99%
“…Proliferation speed and the number of these cells decreases with age, thus reducing the levels of immune protection and increasing the number of pathologically altered cells in the body. Notable increases in the number of cancer cells are observed during the rapid invasive growth of GBM, resulting in the destruction of neurons and glial cells, inflammation, cerebral ischemia and the intensified production of chemo-attractants that stimulate the migration of HSCs into the brain (150).…”
Section: Hscs and Itmentioning
confidence: 99%