Novel chitosan wound dressing loaded with minocycline for the treatment of severe burn wounds

Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications

“…Consequently, the addition of drugs to the composite nanofibrous mat is essential to provide a septic environment for the injured site to heal more easily. There are several therapeutic agents or antibiotics that have been used to serve this purpose, such as gentamicin sulfate, 27 minocycline, 28 norfloxacin, 29 and chlorhexidine. 30,31 Chlorhexidine is an antiseptic included in several biomedical applications, including disinfectants and antibacterial agents that are non-toxic to mammalian cells, due to its subsensitivity for skin, low irritation, and role against a wide range of microorganisms such as Gram-negative and Gram-positive bacteria and fungi.…”

Gentamicin coating of nanotubular anodized titanium implant reduces implant-related osteomyelitis and enhances bone biocompatibility in rabbits

“…Various antibiotic-eluting devices and materials have been reported in joint arthroplasty, such as nondegradable materials like spacer beads and polymethylmethacrylate bone cements, titanium implants, [15][16][17] biodegradable materials such as poly-(lactide-co-glycolide) copolymers, [18][19][20] polycaprolactone, 21,22 polyanhydrides, 23,24 polyhydroxybutyrate-co-hydroxyvalerate 25,26 and polyhydroxyalkanoates 27 and natural polymers such as collagen 28,29 and chitosan. 30,31 Titanium and titanium alloys are widely used as orthopedic implants due to their ideal mechanical properties and satisfactory biocompatibility. The adoption of nanotechnology has promoted the development of novel orthopedic implant materials with ideal properties, such as better cytocompatibility and the ability to be used as specific drug delivery platforms.…”

Studies on the use of recombinant spider silk protein/polyvinyl alcohol electrospinning membrane as wound dressing

“…bFGF expression is weakly positive in normal skin tissue, but strongly positive in inflammatory cells, impaired glands, and epidermis around the wound. 21 On day 5, bFGF showed strong positive expression, and the expression level of the positive control group and the experimental group was both higher than that of the negative control group. On day 7, the bFGF expression of the three groups was significantly lower than those of days 3 and 5, which reflected that the amount of inflammatory cells significantly decreased.…”