Novel circular DNA viruses in stool samples of wild-living chimpanzees

Blinkova, Olga; Victoria, Joseph; Li, Yingying; Keele, Brandon F.; Sanz, Crickette; Ndjango, Jean-Bosco N.; Peeters, Martine; Travis, Dominic A.; Lonsdorf, Elizabeth V.; Wilson, Michael L.; Pusey, Anne E.; Hahn, Beatrice H.; Delwart, Eric

doi:10.1099/vir.0.015446-0

Cited by 101 publications

(77 citation statements)

References 59 publications

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“…Circovirus-like SF pork NW2 P7 genome is unusually small and only loosely related to circoviruses or cycloviruses and because of its unusual genome size and organization, its classification remains uncertain. The detection of apparently truncated circular DNA genome is reminiscent of that reported for a distantly related group of circular DNA viruses (ChiSCV) recently detected in chimpanzee stool (Blinkova et al, 2010) and could reflect the presence of defective genome requiring trans-complementation by a helper virus.…”

mentioning

confidence: 59%

Possible cross-species transmission of circoviruses and cycloviruses among farm animals

Shan

Soji

et al. 2010

Journal of General Virology

127

118

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Circoviruses consist of highly prevalent and genetically diverse porcine and avian pathogens. The genomes of cycloviruses, a proposed new genus in the family Circoviridae, were recently identified in human and chimpanzee faeces. Here, six cyclovirus and four circovirus genomes from the tissues of chickens, goats, cows, and a bat were amplified and sequenced using rolling-circle amplification and inverse PCR. A goat cyclovirus was nearly identical to a cyclovirus from a cow. USA beef contained circoviruses with .99 % similarity to porcine circovirus 2b. Circoviruses in chicken were related to those of pigeons. The close genetic similarity of a subset of cycloviruses and circoviruses replicating in distinct animal species may reflect recent cross-species transmissions. Further studies will be required to determine the impact of these highly prevalent infections on the health of farm animals.

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confidence: 59%

Possible cross-species transmission of circoviruses and cycloviruses among farm animals

Shan

Soji

et al. 2010

Journal of General Virology

127

118

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“…Thus far, none of these viruses have been cultured or found in animal tissue sample. Nonetheless, the viruses have been discovered using viral metagenomics approaches and for the majority of the smacoviruses, the validity of genome sequences has been verified by either PCR amplification using abutting primers followed by Sanger sequencing of these products or by amplification, cloning and Sanger sequencing of the recombinant plasmids [1,3,4,9,15,22,24]. Camel associated porprismacovirus 1…”

mentioning

confidence: 99%

Smacoviridae: a new family of animal-associated single-stranded DNA viruses

Varsani

Krupovìč

2018

Arch Virol

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Smacoviruses have small (∼2.3-2.9 kb), circular single-stranded DNA genomes encoding rolling circle replication-associated proteins (Rep) and unique capsid proteins. Although smacoviruses are prevalent in faecal matter of various vertebrates, including humans, none of these viruses have been cultured thus far. Smacoviruses display ∼45% genome-wide sequence diversity, which is very similar to that found within other families of circular Rep-encoding single-stranded (CRESS) DNA viruses, including members of the families Geminiviridae (46% diversity) and Genomoviridae (47% diversity). Here, we announce the creation of a new family Smacoviridae and describe a sequence-based taxonomic framework which was used to classify 83 smacovirus genomes into 43 species within six new genera, Bovismacovirus (n=3), Cosmacovirus (n=1), Dragsmacovirus (n=1), Drosmacovirus (n=3), Huchismacovirus (n=7), and Porprismacovirus (n=28). As in the case of genomoviruses, the species demarcation is based on the genome-wide pairwise identity, whereas genera are established based on the Rep amino acid sequence identity coupled with strong phylogenetic support. A similar sequence-based taxonomic framework should guide the classification of an astonishing diversity of other uncultured and currently unclassified CRESS DNA viruses discovered by metagenomic approaches.

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“…Metagenomics studies of animal feces have similarly shown frequent coinfections and yielded highly divergent viral species (10,16,25,30,43,44,50,52,53,57,60,61,64).…”

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confidence: 99%

Acute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus

Phan

Bonkoungou

et al. 2012

J Virol

136

144

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g Parvoviruses cause a variety of mild to severe symptoms or asymptomatic infections in humans and animals. During a viral metagenomic analysis of feces from children with acute diarrhea in Burkina Faso, we identified in decreasing prevalence nucleic acids from anelloviruses, dependoviruses, sapoviruses, enteroviruses, bocaviruses, noroviruses, adenoviruses, parechoviruses, rotaviruses, cosavirus, astroviruses, and hepatitis B virus. Sequences from a highly divergent parvovirus, provisionally called bufavirus, were also detected whose NS1 and VP1 proteins showed <39% and <31% identities to those of previously known parvoviruses. Four percent of the fecal samples were PCR positive for this new parvovirus, including a related bufavirus species showing only 72% identity in VP1. The high degree of genetic divergence of these related genomes from those of other parvoviruses indicates the presence of a proposed new Parvoviridae genus containing at least two species. Studies of the tropism and pathogenicity of these novel parvoviruses will be facilitated by the availability of their genome sequences.

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Novel circular DNA viruses in stool samples of wild-living chimpanzees

Cited by 101 publications

References 59 publications

Possible cross-species transmission of circoviruses and cycloviruses among farm animals

Possible cross-species transmission of circoviruses and cycloviruses among farm animals

Smacoviridae: a new family of animal-associated single-stranded DNA viruses

Acute Diarrhea in West African Children: Diverse Enteric Viruses and a Novel Parvovirus Genus

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