Novel citrinin derivatives from fungus Penicillium sp. TW131-64 and their antimicrobial activities

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

“…These products exhibited potential anti-H. pylori activities towards the standard strain and multidrug-resistant clinical isolates with MIC values ranging from 0.25 to 8 µg/mL, indicating a comparable or even better killing activity than metronidazole. Citrinin derivatives (3R,4S)-8-hydroxy-6-methoxy-3,4,5-trimethylisochromane-7-carboxylatemethyl ( 56), (3R,4S)-6-hydroxy-8-methoxy -3,4,5trimethylisochromane-7-carboxy latemethyl (57), and penicitrinone J (58) (Figure 2) were also obtained from this strain [33]. Rare carbon-bridged citrinin dimers, dicitrinones G-J (59-62) (Figure 2) were isolated from starfish-derived Penicillium sp.…”

“…BJR-P2. Pannicillol B (33) exhibited significant inhibitory activity on NO production with an IC 50 value of 12 µM [27]. Peniciisocoumarins I (34) and J (35) (Figure 1) were obtained from the mangrove-derived Penicillium sp.…”

“…BJR-P2. Pannicillol B (33) exhibited significant inhibitory activity on NO production with an IC50 value of 12 μM [27]. Peniciisocoumarins…”

“…Citrinins, as an important class of polyketide mycotoxins, usually have core structure skeletons like benzopyran, benzofuran, and quinone-pyran, etc. [33]. Three extremely rare nitrogen-containing citrinin derivatives, isoquinocitrinins B-D (53)(54)(55), and their corresponding enantiomers (53a/b, 54a/b, 55a/b) (Figure 2) were acquired from the hydrothermal-vent-sediment-derived Penicillium sp.…”