Novel clinical and serological aspects in non-allergic asthma

Comi, Alessandro; Tedeschi, A.; Lorini, M.; Miadonna, A.

doi:10.1016/j.rmed.2007.07.010

Cited by 23 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The disease could be triggered by one or more of the following mechanisms: hypersensitivity reactions to unidentified allergens such as fungi, recurrent or persistent infections, and autoimmune mechanisms [16,17,18,19,20]. …”

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

show abstract

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Ogólne doświad czenia, w tym członków panelu, są takie, że u zdro wych osób z grupy kontrolnej i u pacjentów bez objawów PPS wynik ASST nigdy nie jest dodatni, a zatem nie stwierdza się reakcji miejscowej zdefi niowanej jako powstanie zapalnego bąbla o rumie niowym zabarwieniu [48][49][50][51][52][53][54][55][56][57][58][59][60]. W przeciwieństwie do większości wcześniej opublikowanych badań, niektóre prace wykazują relatywnie wysoki odse tek dodatniej reakcji w ASST u chorych z alergicz nymi lub niealergicznymi objawami ze strony ukła du oddechowego, wynoszący 30-50% u dorosłych pacjentów i aż do 80% w populacji dziecięcej [53][54][55][56]61]. W dwóch z tych badań u 40-45% zdrowych osób także uzyskano dodatni wynik ASST, choć jako kryterium wyniku dodatniego zostały przyjęte dane zatwierdzone tylko dla pokrzywki przewle kłej.…”

unclassified

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Zuberbier¹,

Aberer²,

Asero³

et al. 2015

View full text Add to dashboard Cite

“…Correlations of asthma with the prevalence of various autoimmune diseases such as Type I diabetes [5], rheumatoid arthritis [6], etc have been demonstrated. Additionally, there is evidence for a variety of auto-antibodies in patients with asthma such as anti-nuclear [7–9], anti-β 2 –adrenergic receptor [10, 11], anti-bronchial epithelial cytokeratin 18 [12], anti-alpha enolase [13, 14], and antibodies (Abs) to IgE and the high affinity IgE receptor – FcεRI [15]. However the role of these Abs in asthma still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Immune responses to self-antigens in asthma patients: clinical and immunopathological implications

et al. 2012

View full text Add to dashboard Cite

Asthma leads to chronic airway inflammation that shares pathological features of chronic rejection after lung transplantation. Due to significant role of autoimmunity in chronic rejection, we hypothesized that immunity to self-antigens may also be present in asthma. The goal was to define immune responses to self-antigens in patients with asthma. Blood and clinical data were collected from 99 asthmatics and 60 controls. Serum was analyzed for antibodies (Abs) to Collagen V (ColV) by ELISA and correlated with disease severity. Asthmatics' sera were tested in human protein array to determine immune responses to other self-antigens. Asthmatics had higher concentration of Abs to ColV (predominantly IgG isotype) compared to control (p < 0.01). These Abs correlated with severe asthma (p<0.01) and corticosteroid use (p=0.032). Additionally, Abs to novel self-antigens epidermal group factor receptor (EGFr), activin A type 1 receptor, and alpha-catenin (α-catenin) were detected in asthmatics. We conclude that Abs to self-antigens (ColV, EGFr, Activin A type 1 receptor, and α-catenin) are present in asthmatics sera correlating with clinical disease. Epithelial damage from airway inflammation during asthma may result in exposure of cryptic self-antigens or their determinants resulting in immune response to self-antigens and these may contribute to pathogenesis of asthma.

show abstract

Novel clinical and serological aspects in non-allergic asthma

Cited by 23 publications

References 30 publications

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Immune responses to self-antigens in asthma patients: clinical and immunopathological implications

Contact Info

Product

Resources

About