Novel Clinical Trial Designs in Neuro-Oncology

Patient, Relative and Staff Experiences of Clinical Trial Participation in Neurooncology: “Maybe You Can Also Show the Positive, No Matter How It Ends”

“…This may be especially relevant when thinking about new trial concepts such as umbrella trials, which are highly relevant for state-of-the-art brain tumor research. 27 , 28 …”

“…This may be especially relevant when thinking about new trial concepts such as umbrella trials, which are highly relevant for state-of-the-art brain tumor research. 27,28 Staff interviewees of our study often presented being informed versus being hopeful in an either-or-context. But in our analysis, we found that these conditions often existed in parallel -even though they could differ in their character and, depending on the situation, one could be perceived as more important than the other.…”

Therapeutic Advances in Neuro-Oncology

“…Our final two articles ponder ways to improve clinical trial design and response assessment. Saraf et al [16] discuss the pros and cons of novel clinical trial concepts such as master protocol trials, response-based adaptive randomization, and platform trial infrastructures. Ellingson et al introduce us to the concept of quantifying therapeutic response using control systems theory [17].…”