2006
DOI: 10.1182/blood-2005-06-2218
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Novel collectin/C1q receptor mediates mast cell activation and innate immunity

Abstract: Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are poorly defined. The ␣ 2 ␤ 1 integrin, a receptor for collagens, laminins, decorin, Ecadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several viruses, has been implicated in normal developmental, inflammatory, and oncogenic processes. We recently reported that ␣ 2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and IL… Show more

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Cited by 72 publications
(84 citation statements)
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“…It has been reported that extracellular matrix proteins (i.e. fibronectin, fibrinogen, and collagen) affect degranulation by mast cells in addition to their adhesion, migration, and inflammatory responses by binding a wide array of integrins expressed by mast cells [44][45][46]. OPN-induced migration by FSMC was virtually blocked by Ab against either CD44 or integrin av (Fig.…”
Section: Discussionmentioning
confidence: 93%
“…It has been reported that extracellular matrix proteins (i.e. fibronectin, fibrinogen, and collagen) affect degranulation by mast cells in addition to their adhesion, migration, and inflammatory responses by binding a wide array of integrins expressed by mast cells [44][45][46]. OPN-induced migration by FSMC was virtually blocked by Ab against either CD44 or integrin av (Fig.…”
Section: Discussionmentioning
confidence: 93%
“…We first examined a constitutively activating mutant E318A (pictured in Fig. 1) in the ␣ 2 chain of the full-length integrin (33). This mutant disrupts a salt bridge in the I-domain that is critical to the stability of the closed conformation of the integrin, bypassing the requirement for an interaction between the ␣ 2 I-domain and the ␤ 1 I-like domain to achieve the activated conformation (15,34).…”
Section: Determining Of the Ring Geometry Of The Pro Analog In Integrmentioning
confidence: 99%
“…In a recent study, it was shown that IL-6 induction from mast cells, by antibody-opsonized bacteria L. monocytogenes, is dependent on the presence of C1q and integrin α2β1 expression on mast cells (107). Antibody-opsonized L. monocytogenes failed to induce IL-6 from mast cells when either C1q -/-mouse serum or α2 -/-mast cells were used.…”
Section: C1q Regulates Granulocytes Mast Cells and Fibroblastsmentioning
confidence: 99%
“…Antibody-opsonized L. monocytogenes failed to induce IL-6 from mast cells when either C1q -/-mouse serum or α2 -/-mast cells were used. It suggests that bacteria-bound C1q engages integrin α2β1 to provide a co-stimulatory signal through α2β1 signaling which synergizes with other receptors, i.e., FcR and CR, to induce IL-6 from mast cells (107). Mast cells adhere to immobilized C1q through the α2β1 integrin (107).…”
Section: C1q Regulates Granulocytes Mast Cells and Fibroblastsmentioning
confidence: 99%