Novel compounds with dual inhibition activity against SARS-CoV-2 critical enzymes RdRp and human TMPRSS2

Soliman, Sameh S.M.; Hamoda, Alshaimaa M.; Nayak, Yogendra; Mostafa, Ahmed; Hamdy, Rania

doi:10.1016/j.ejmech.2024.116671

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2024.116671

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Novel compounds with dual inhibition activity against SARS-CoV-2 critical enzymes RdRp and human TMPRSS2

Sameh S.M. Soliman,

Alshaimaa M. Hamoda,

Yogendra Nayak

et al.

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Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

Navacchia,

Cinti,

Marchesi

et al. 2024

Molecules

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The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral anti-SARS-CoV-2 activity.

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Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

Navacchia,

Cinti,

Marchesi

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Novel compounds with dual inhibition activity against SARS-CoV-2 critical enzymes RdRp and human TMPRSS2

Cited by 1 publication

References 65 publications

Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

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