Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft

Nikolavsky, Dmitriy; Manwaring, Jared; Bratslavsky, Gennady; Caza, Tiffany; Landas, Steve K.; Hryniewicz-Jankowska, Anita; Kotula, Leszek

doi:10.1016/j.juro.2016.05.028

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…Nikolavsky et al . reported a novel method of urethral stricture treatment by injection of autologous liquid buccal mucosa grafts suspended in fibrin glue in combination with DVIU in a rabbit model, suggesting the possibility of endoscopic buccal mucosa cell implantation in urethral wounds . In the present study, Vaddi et al .…”

supporting

confidence: 49%

“…Nikolavsky et al reported a novel method of urethral stricture treatment by injection of autologous liquid buccal mucosa grafts suspended in fibrin glue in combination with DVIU in a rabbit model, suggesting the possibility of endoscopic buccal mucosa cell implantation in urethral wounds. 4 In the present study, Vaddi et al further advanced this concept and carried out a preliminary study examining the feasibility of a cell-based endoscopic technique using buccal mucosa cells encapsulated in a thermoreversible gelation polymer scaffold in six male patients with bulbar urethral stricture. 5 Although all six patients had a stricture >2-cm long, which are theoretically difficult to be cured by DVIU alone, four of them achieved relatively long-term stricture-free status by this endoscopic technique.…”

mentioning

confidence: 91%

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Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

Horiguchi

2018

Int J of Urology

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supporting

confidence: 49%

mentioning

confidence: 91%

Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

Horiguchi

2018

Int J of Urology

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“…Following the inclusion and exclusion criteria, a total of 43 studies were selected for full-text reading ( Figure 1 ). Only 28 studies were considered eligible for quality appraisal [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. These studies comprise a range of approaches and scaffolds for urethral repair in rabbits, which are summarized in the Supplementary Table S2 .…”

Section: Resultsmentioning

confidence: 99%

Quality of Reporting in Preclinical Urethral Tissue Engineering Studies: A Systematic Review to Assess Adherence to the ARRIVE Guidelines

Abbas

Elawad

Pullattayil

et al. 2021

Animals

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Preclinical research within the area of urethral tissue engineering has not yet been successfully translated into an efficient therapeutic option for patients. This gap could be attributed, in part, to inadequate design and reporting of the studies employing laboratory animals. In this study, a systematic review was conducted to investigate the quality of reporting in preclinical studies utilizing tissue engineering approaches for urethral repair. The scope was on studies performed in rabbits, published between January 2014 and March 2020. Quality assessment of the data was conducted according to the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines by the scoring of a 38-item checklist in different categories. A total of 28 articles that fulfilled the eligibility criteria were included in the study. The range of ARRIVE score was from 0 to 100, taking into consideration having reported the item in question or not. The mean checklist score was 53%. The items that attained the highest scores included the number of animals utilized, the size of control and experimental groups, and the definition of experimental outcomes. The least frequently reported items included the data regarding the experimental procedure, housing and husbandry, determination and justification of the number of animals, and reporting of adverse events. Surprisingly, full disclosure about ethical guidelines and animal protocol approval was missing in 54% of the studies. No paper stated the sample size estimation. Overall, our study found that a large number of studies display inadequate reporting of fundamental information and that the quality of reporting improved marginally over the study period. We encourage a comprehensive implementation of the ARRIVE guidelines in animal studies exploring tissue engineering for urethral repair, not only to facilitate effective translation of preclinical research findings into clinical therapies, but also to ensure compliance with ethical principles and to minimize unnecessary animal studies.

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“…Reconstruction of local anatomic disorder and function might be an alternative approach to cure esophageal restenosis. As recommended, oral mucosal transplantation is an effective technique for treating ureteral or urethral strictures [5,12]. There have been no reports of mucosal grafting to treat esophageal strictures, although gastric mucosal transplantation has been introduced to prevent esophageal stricture after circumferential ESD with promising results [13].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic mucosal autograft for treating esophageal caustic strictures: preliminary human experience

Zhao

et al. 2018

Endoscopy

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Esophageal caustic stricture is a stubborn disease and postoperative restenosis limits the clinical efficacy of endoscopic dilation. Autologous mucosal grafts have been successfully applied in the treatment of urethral stricture and in the prevention of stricture after extensive mucosal resection. We aimed to use mucosal autografting performed endoscopically to treat refractory esophageal stricture. METHODS : Three patients with intractable corrosive esophageal stricture were treated endoscopically by combining dilation with autologous mucosal transplantation. RESULTS : All procedures were successful with no severe complications. Mucosal regeneration was shown at the transplanted segments. One patient was able to maintain a normal diet with complete remission after 1 year of follow-up. Intraluminal stenosis and dysphagia were significantly improved in another two patients. CONCLUSIONS : Mucosal autografting can achieve esophageal re-epithelialization, inhibit undesired fibrosis, prevent restenosis, and promote functional regeneration.

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Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft

Abstract: This proof of concept study demonstrated the feasibility of using liquid buccal mucosal grafts for endoscopic urethral stricture repair. Such a method may allow for wide application of this novel concept of using liquid buccal mucosal grafts to augment direct vision internal urethrotomy.

Cited by 12 publications

References 26 publications

Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

Editorial Comment from Dr Horiguchi to Buccal epithelium Expanded and Encapsulated in Scaffold‐Hybrid Approach to Urethral Stricture (BEES‐HAUS) procedure: A novel cell therapy‐based pilot study

Quality of Reporting in Preclinical Urethral Tissue Engineering Studies: A Systematic Review to Assess Adherence to the ARRIVE Guidelines

Endoscopic mucosal autograft for treating esophageal caustic strictures: preliminary human experience

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