Novel controlled drug release system engineered with inclusion complexes based on carboxylic graphene

Xiao, Yinghong; Zhang, Ming; Fan, Yunting; Zhang, Qicheng; Wang, Yuli; Yuan, Wenwen; Zhou, Ninglin; Che, Jianfei

doi:10.1016/j.colsurfb.2018.11.058

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…In vitro cytotoxicity tests proved that the nanospheres were not toxic and are suitable for intravenous use with suitable blood compatibility. It was observed that the biological effects of DEX were not influenced by incorporation into the NC [149].…”

Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Figure 11mentioning

confidence: 99%

Graphenic Materials for Biomedical Applications

2019

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“…For the drug delivery systems, their blood compatibility is a must concern. Their interactions with the compositions of blood are considered as the serious limitation in clinical, and their nonspecific interactions could even severely diminish the half-life and targeting of drugs (Xiao et al., 2019). The blood compatibility of Tf-PAAs-MTX/pMMP-9 was assessed by spectrophotometric measurement of hemoglobin released from erythrocytes after Tf-PAAs-MTX/pMMP-9 treatment.…”

Section: Resultsmentioning

confidence: 99%

A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

Liu

Wu²,

Chen

et al. 2019

Drug Delivery

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To obtain a high-efficiency drug and gene co-delivery system to HNE-1 tumor therapy, a polymeric prodrug (PAAs-MTX) with chemotherapeutic sensibilization was synthesized consisting of a GSHresponse hyperbranched poly(amido amine) (PAAs) and an antitumor drug of methotrexate (MTX). Then, the targeting molecule to HNE-1 cells, transferrin (Tf), was conjugated to form the Tf-PAAs-MTX. This polymeric prodrug could deliver MMP-9 shRNA plasmid (pMMP-9) again to form the drug and gene co-delivery system of Tf-PAAs-MTX/pMMP-9. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency to HNE-1 cells. Besides that, Tf-PAAs-MTX also showed the chemotherapeutic sensibilization effect, the formulation containing PAAs segments showed much higher cytotoxicity than that of free MTX. Benefiting from the sensibilization effect and MTX/pMMP-9 co-delivery strategy, this Tf-PAAs-MTX/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by in vitro and in vivo assays. Moreover, its biocompatibility, especially the blood compatibility was analyzed. This polymeric prodrug provided an easily delivery system combining the drug/gene co-delivery, chemotherapeutic sensibilization and targeting into one single platform, which showed a promising application in nasopharyngeal carcinoma therapy.

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“…To better reveal the rules of controlled release of drugs, the following classical kinetic models were used to study the drug release mechanism, namely, the zero-order, first-order, Higuchi, and Bhaskar models, respectively. [35][36][37][38][39] Zero-order…”

Section: Analysis Of Release Mechanism and Mathematical Model Fittingmentioning

confidence: 99%

Alkaline media‐sensitive nanocarrier based on carboxylated cyclodextrin for targeted delivery of anti‐colon drug

Chen

Zhu

et al. 2022

J of Applied Polymer Sci

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The pH‐responsive nanoparticles are a promising drug‐carrier because they always showed sensitivity and specificity to the pH changes caused by the surrounding environment. Most of the therapeutic drugs are generally absorbed in the stomach and small intestine due to the pH‐responsive nanoparticles always release the cargos at acidic media, making them difficult to reach the lower part of the large intestine, as well as inhibiting the therapeutic effects. Herein, an alkaline media‐sensitive supramolecular nanoparticle, regarded as SACD/PEI NPs, is prepared. SACD/PEI NPs exhibit assemble/disassemble state by changing the pH, which is used to encapsulate the anti‐colon drug CSL. CSL@SACD/PEI NPs showed a high release rate of 86.1% for the encapsulated CSL at pH = 8.5 (mimic the colon micro‐environment), while keeping stable at pH = 1.2 (mimic the gastric acid micro‐environment). Meanwhile, CSL@SACD/PEI NPs exhibited low hemolysis, indicating they possess good biocompatibility. In cell experiments, CSL@SACD/PEI NPs had a similar inhibitory effect on colon tumor cell SW480 and showed low cytotoxicity to normal cells compared with free CSL. Furthermore, both free CSL and CSL@SACD/PEI NPs showed excellent apoptosis effects on tumor cell SMMC‐7721. We hope that CSL@SACD/PEI NPs could be the valuable base‐answered drug delivery candidate, and have potential application for colon tumor therapy.

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Novel controlled drug release system engineered with inclusion complexes based on carboxylic graphene

Cited by 10 publications

References 32 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

Alkaline media‐sensitive nanocarrier based on carboxylated cyclodextrin for targeted delivery of anti‐colon drug

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