Novel Copper (Cu) Loaded Core–Shell Silica Nanoparticles with Improved Cu Bioavailability: Synthesis, Characterization and Study of Antibacterial Properties

Maniprasad, Pavithra; Santra, Swadeshmukul

doi:10.1166/jbn.2012.1423

Cited by 41 publications

(19 citation statements)

References 22 publications

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“…Maniprasad and Santra (2012) developed novel core-shell silica structures containing highly dispersed Cu NPs. The bioavailability of these antimicrobial NPs had lower MIC values against E. coli and B. subtilis than copper hydroxide particles in suspension [143].…”

Section: Silica-and Carbon-derived Nanoparticlesmentioning

confidence: 95%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

115

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The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

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Section: Silica-and Carbon-derived Nanoparticlesmentioning

confidence: 95%

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Correa

Martínez

Vidal

et al. 2020

Beilstein J. Nanotechnol.

115

View full text Add to dashboard Cite

show abstract

“…SiO 2 core-shell nanoparticles containing approximately 0.1 μg of Cu (in the form of insoluble copper hydroxide) possessed significantly better antibacterial properties against Escherichia coli and Bacillus subtilis bacteria than those observed for Cu(OH) 2 alone [44]. In the case of coreshell CuSiO 3 structures the minimum concentration inhibiting the growth of these bacteria was 2.4 μg Cu/mL.…”

Section: N Introductionmentioning

confidence: 91%

Antimicrobial Functionalization of Textile Materials with Copper Silicate

Sójka-Ledakowicz¹,

Chruściel²,

Kudzin³

et al. 2016

F&TinEE

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A biofunctionalization of nonwoven fabrics was carried out with 0.1-4 wt.% of copper silicate. Polypropylene (PP), polyethylene (PE) and biodegradable polymers [poly(lactic acid) (PLA), polyhydroxyalkanoates (PHA)] or their mixtures were used as polymer components. Mostly liquid oligomers of ethylene glycol (PEG) or copolymers of ethylene oxide and propylene oxide (2.5-5 wt.%) were applied as plasticizers. New composite nonwovens containing CuSiO 3 were prepared by the melt-blown technique [1]. They showed very good antibacterial and antifungal properties against colonies of gram-negative bacteria (Escherichia coli), gram-positive bacteria (Staphylococcus aureus) and a yeast fungus (Candida albicans). Nonwovens containing ≥ 0.5 wt.% of CuSiO 3 can be used, e.g. as hygienic and bioactive filter materials in airconditioning systems. The application of PLA and PHA affects the ability of these hybrid nonwovens to biologically decompose. DSC analysis indicated that the incorporation of additives in PLA and PP nonwovens significantly affected their melting and crystallization processes.

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“…Compositing Cu with SiNPs can help in sustained release of Cu to exert antibacterial activity. Synthesis of core-shell copper-silica nanoparticles for antimicrobial activity was reported by Maniprasad and Santra ( 2012 ). The results indicated that the core-shell nanoconstructs exhibited better antibacterial efficacy against E. coli and B. subtilis than the insoluble Cu-OH particles.…”

Section: Applications Of Silica Nanoparticles In Antimicrobial Therapmentioning

confidence: 99%

Silica Nanoparticles—A Versatile Tool for the Treatment of Bacterial Infections

2020

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The rapid emergence of drug resistance continues to outpace the development of new antibiotics in the treatment of infectious diseases. Conventional therapy is currently limited by drug access issues such as low intracellular drug accumulations, drug efflux by efflux pumps and/or enzymatic degradation. To improve access, targeted delivery using nanocarriers could provide the quantum leap in intracellular drug transport and retention. Silica nanoparticles (SiNPs) with crucial advantages such as large surface area, ease-of-functionalization, and biocompatibility, are one of the most commonly used nanoparticles in drug delivery applications. A porous variant, called the mesoporous silica nanoparticles (MSN), also confers additional amenities such as tunable pore size and volume, leading to high drug loading capacity. In the context of bacterial infections, SiNPs and its variants can act as a powerful tool for the targeted delivery of antimicrobials, potentially reducing the impact of high drug dosage and its side effects. In this review, we will provide an overview of SiNPs synthesis, its structural proficiency which is critical in loading and conjugation of antimicrobials and its role in different antimicrobial applications with emphasis on intracellular drug targeting in anti-tuberculosis therapy, nitric oxide delivery, and metal nanocomposites. The role of SiNPs in antibiofilm coatings will also be covered in the context of nosocomial infections and surgical implants.

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Novel Copper (Cu) Loaded Core–Shell Silica Nanoparticles with Improved Cu Bioavailability: Synthesis, Characterization and Study of Antibacterial Properties

Cited by 41 publications

References 22 publications

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Antimicrobial Functionalization of Textile Materials with Copper Silicate

Silica Nanoparticles—A Versatile Tool for the Treatment of Bacterial Infections

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