Aim: This study aims to assess the knowledge, awareness, and practices of registered dentists regarding COVID-19 epidemiology and transmission during the rapid outbreak of this highly contagious virus in Bangladesh. Subjects and Methods: A cross-sectional web-based survey was conducted among the dentists who were enrolled with their valid unique Bangladesh Medical and Dental Council (BMDC) registration number. A validated questionnaire was developed and distributed among the dentists by using different social media platforms. A total of 184 dentists participated in the survey between March and April 2020. Both descriptive analysis logistic regression analysis was performed.Results: The mean age of the dentists is 31.75 years, with a standard deviation of 6.5 years. About 29.3% of dentists completed their postgraduate qualification, and 76% of them are engaged in private practice. The dentists who completed postgraduate education are three times more likely to know (OR=3.1, 95%CI 1.2-7.9) about COVID-19 compared to the dentists who completed an undergraduate degree. It is also observed that the dentists who are employed in private and independent settings are four times (OR=4, 95%CI 0.7-24) more likely to follow safe practice compared to the dentists who are engaged in the government hospitals or clinics.Conclusion: The dentists from Bangladesh have shown good knowledge, awareness, and practice regarding COVID-19. We recommend that the healthcare authorities, professional organizations, and hospitals coordinate, and conduct mandatory advanced infectious disease training for all the practicing dentists in the country.