We present a case of COVID-19 patient, who had multiple comorbidities, including diabetes mellitus, bronchial asthma, morbid obesity (BMI:48) and obstructive sleep apnea. She had good compliance with CPAP treatment. After a vacation, she developed typical symptoms of COVID-19, including fever, cough with blood tinged sputum and shortness of breath. She had to be treated with polypharmacy for all of her concurrent diseases. Her hypoxia responded well to oxygen therapy. Laboratory reports and chest x-rays presented a typical picture of COVID-19, including lymphopenia and lung infiltrates. Patient received inj. ceftriaxone, inj. azithromycin and hydroxychloroquine, to which her response was quite satisfactory and after two weeks, she was discharged and shifted to home.