Novel Coronavirus Disease (COVID-19): An extensive study on evolution, global health, drug targets and vaccines

Abstract

The Coronavirus disease-2019 (COVID-19), has become a worldwide pandemic and the scientific communities are struggling to find out the ultimate treatment strategies against this lethal virus, Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2). Presently, there is no potential chemically proven antiviral therapy available in the market which can effectively combat the infection caused by this deadly virus. Few vaccines are already developed but it is not clear to the scientific community how much efficient they are to combat SARS-CoV-2. Mode of transmission and symptoms of the disease are two important factors in this regard. Rapid diagnosis of the COVID-19 is very much important to stop its spreading. In this scenario, a complete study starting from symptoms of the disease to vaccine development including various SARS-CoV-2 detection techniques is very much required. In this review article, we have made a partial analysis on the origin, virology, global health, detection techniques, replication pathways, doses, mode of actions of probable drugs, and vaccine development for SARS-CoV-2.

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“…Golgi intermediate compartment (ERGIC) complex [58]. At the same time, ribonucleoprotein is formed by the complexion of replicated genome and N protein and new virions are released by exocytosis from ERGIC [59,60]. The step by step translation and replication process of CoV in the host cell is depicted in igure 6.…”

“…Ribavirin (tribavirin) [105,[119][120][121][122] Ribavirin is a nucleoside inhibitor which is used to stop viral RNA synthesis and viral mRNA capping.…”