Novel Coumarin Derivatives with Expected Biological Activity

Nofal, Z. M.; El-Zahar, Magdy I.; El-Karim, Somaia S. Abd

doi:10.3390/50200099

Cited by 217 publications

(130 citation statements)

References 9 publications

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“…Coumarin and its derivatives represent one of the most active classes of compound possessing a wide spectrum of biological activity [1][2][3][4]. The synthesis of coumarin derivatives has attracted considerable attention of organic and medicinal chemists as these are widely used as therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

Mishra

Rathod

Namera

et al. 2014

ILCPA

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We have reported some novel N'-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1 H NMR, 13 C NMR and elemental analysis. Moreover, all synthesized compounds were screened for in vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which some the compounds show potential inhibition against the test organisms.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

Mishra

Rathod

Namera

et al. 2014

ILCPA

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“…In view of this, coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Hence, many researchers have reported different biological activities of coumarins derivatives such as anticoagulant, antitubercular, antileucemic, antimicrobial, anti-inflammatory, anti-HIV, analgesic, anticancer, antitumoral, anticonvulsant, antiplatelet, antifungal, antiviral, antibacterial, antimalarial activities and other pharmacological activities [3][4][5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Testing of Biological Activity of Some Novel Chalcones Derivatives of Coumarin

Deshpande¹,

Chopde²,

Pandhurnekar³

et al. 2013

Chem Sci Trans

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Abstract:In the present communication, we herein report the synthesis of some novel derivatives of coumarin i.e. 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl)phenyl)acryloyl)-2H-chromen-2-one (2a-2g). Various aromatic amines and salicylaldehyde in the presence of sodium nitrite and conc. HCl yielded 2-hydroxy-5-((aryl)diazenyl)benzaldehyde (1a-1g). A series of 3-((2E)-(3-(2-hydroxy-5-((aryl)diazenyl) phenyl)acryloyl)-2H-chromen-2-one were synthesized by the reaction of 2-hydroxy-5-((aryl)diazenyl) benzaldehyde and coumarin in presence of ethanol and piperidine. Different analytical techniques such as elemental analysis, IR spectra, 1 H NMR spectra and mass spectra were used to elucidate the structures of all newly synthesized compounds (1a-1g and 2a-2g). The anti-bacterial and anti-fungal activity of newly synthesized chalcone derivatives (2a-2g) were evaluated against different bacterial and fungal stains. Some of these compounds showed promising activity against different stains.

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“…Coumarin itself and 7-hydroxycoumarin have been reported to inhibit the proliferation of a number of human malignant cell lines in vitro [2][3][4][5], and have demonstrated activity against several types of animal tumors [6][7][8][9][10].…”

Section: -Hydroxy Coumarinmentioning

confidence: 99%

Synthesis and bio-evaluation of novel 7-hydroxy coumarin derivatives via Knoevenagel reaction

et al. 2013

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Coumarin and 7-hydroxy coumarins have great significance as natural fragrances, having a characteristic odour like vanilla beans and their hydroxy position at 7 has importance in biosynthesis. Treatment of 8-formyl-7-hydroxy coumarin with N,Ndisubstituted cyano acetamides in the presence of piperidine afforded novel 8-substituted-7-hydroxy coumarin derivatives. Their structures were characterized by IR, 1 H, 13 C NMR, mass spectral and elemental analysis data. Two out of these 12 compounds, i.e. 2-Cyano-3-(7-hydroxy-2-oxo-2H-chromen-8-yl)-N-[2-(2-methoxy-phenoxy)-ethyl]-acrylamide and 2-Cyano-N-(2,5-dihydro-thiazol-2-yl)-3-(7-hydroxy-2-oxo-2H-chromen-8-yl)-acryl amide showed enhanced in vitro antifungal activity against Candida albicans and Aspergillus niger vis-à-vis standard, i.e. fluconazole, and enhanced in vitro antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa vis-à-vis standard, i.e. norfloxacin.

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Novel Coumarin Derivatives with Expected Biological Activity

Cited by 217 publications

References 9 publications

Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

Synthesis, Characterization and Testing of Biological Activity of Some Novel Chalcones Derivatives of Coumarin

Synthesis and bio-evaluation of novel 7-hydroxy coumarin derivatives via Knoevenagel reaction

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