Novel cytotoxic nine-membered macrocyclic polysulfur cembranoid lactones from the soft coral Sinularia sp.

Lei, Ling-Fang; Chen, Minfeng; Wang, Tao; He, Xian-Hui; Liu, Bing-Xin; Deng, Yun; Chen, Xiaojie; Li, Yuting; Guan, Shanyue; Jiang, Yao; Li, Wei; Ye, Wen‐Cai; Zhang, Dongmei; Zhang, Cui‐Xian

doi:10.1016/j.tet.2014.07.042

Cited by 18 publications

(17 citation statements)

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“…Of the thirty-six cembrane related metabolites 1113-1149 reported from cnidarians in 2014, [709][710][711][712][713][714][715][716][717][718][719][720][721][722] secocrassumol 1113 (Lobophytun crassum) 709 is notable as it is derived from the cembrane skeleton via an unusual C-11-C-12 bond cleavage, sinugyrosanolide A 1114 (Sinularia gyrosa) is an unprecedented C-4 norcembranoid, 710 tortuosenes A 1146 and B 1147 (Sarcophyton tortuosum) 721 represent the rst examples of cembranoids containing a C-2-C-20 ring closure, and sinularbols A 1148 and B 1149 (Sinularia arborea) contain a rare C-3-C-9 ring closure. 722 Cnidarian chemistry is dominated by metabolites derived from terpene biosynthesis, with particularly large numbers falling into the diterpenoid classication.…”

Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2016

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This review covers the literature published in 2014 for marine natural products (MNPs), with 1116 citations (753 for the period January to December 2014) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1378 in 456 papers for 2014), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2016

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“…Interestingly, the cytotoxic activity of 8 and 152 against the multidrug-resistant cell lines HepG2/ADM and MCF-7/ADM was comparable to that of the positive control doxorubicin. Furthermore, it was found that compound 152 induced apoptosis, and its selective toxicity toward HepG2/ADM cells was not related to P-glycoproteins [122]. In another chemical investigation, Roy et al [123] reported the isolation of two new alcyonolide congeners, trisnorditerpenoid 1 and diterpenoid 2, from the coral Cespitularia sp.…”

Section: Bioactive Compounds From Coralmentioning

confidence: 99%

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

et al. 2019

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Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products that possess a wide range of potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, and antifouling activities, among others, are described in this review.

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“…In previous studies, a series of secondary metabolites, including steroids and cembrane-and capnosane-type diterpenoids, [12][13][14] were isolated from the octocoral Sinularia humilis, and sulfurcontaining natural products were obtained from various octocorals belonging to the genus Sinularia. [9][10][11] Metabolism of the sulfur element was proven to be processed by the associated bacteria. 15,16 To the best of our knowledge, this is the first occasion on which cyclooctasulfur was obtained from a marine invertebrate.…”

Section: Resultsmentioning

confidence: 99%