In the scenario that dark matter (DM) is a weakly interacting massive particle, there are many possibilities of the interactions with the Standard Model (SM) particles to achieve the relic density of DM. In this paper, we consider a simple DM model where the DM candidate is a complex scalar boson. The model contains a new complex gauge singlet scalar boson and a new fermion whose gauge charge is the same as the right-handed down-type quark. We dub the new fermion the bottom partner. These new particles have Yukawa interactions with the SM down-type quarks. The DM candidate interacts with the SM particles through the Yukawa interactions. The Yukawa interactions are not only relevant to the annihilation process of the DM but also contribute to the flavor physics, such as the ∆F = 2 processes. In addition, the flavor alignment of the Yukawa couplings is related to the decay modes of the bottom partner, and thus we can find the explicit correlations among the physical observables in DM physics, flavor physics, and the signals at the LHC. We survey the ∆F = 2 processes based on the numerical analyses of the thermal relic density, the direct detection of the DM, and the current LHC bounds. We investigate the perturbative bound on the Yukawa coupling as well. A Study of a fermionic DM model with extra scalar quarks is also given for comparison.